This HTML5 document contains 64 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n22http://linked.opendata.cz/resource/AHFS/
foafhttp://xmlns.com/foaf/0.1/
n24http://linked.opendata.cz/resource/mesh/concept/
n13http://linked.opendata.cz/resource/drugbank/company/
n12http://linked.opendata.cz/resource/drugbank/dosage/
n11http://linked.opendata.cz/resource/drugbank/drug/DB00016/identifier/drugbank/
n20http://bio2rdf.org/drugbank:
n10http://linked.opendata.cz/resource/drugbank/drug/DB00016/identifier/national-drug-code-directory/
admshttp://www.w3.org/ns/adms#
n18http://www.rxlist.com/cgi/generic/
n26http://linked.opendata.cz/resource/drugbank/patent/
n15http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n9http://linked.opendata.cz/resource/drugbank/drug/DB00016/identifier/genbank/
n6http://linked.opendata.cz/resource/drugbank/medicinal-product/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00016/identifier/uniprotkb/
owlhttp://www.w3.org/2002/07/owl#
n23http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n25http://www.drugs.com/cdi/
n5http://linked.opendata.cz/resource/drugbank/property/
n16http://linked.opendata.cz/resource/drugbank/drug/DB00016/identifier/wikipedia/
n19http://linked.opendata.cz/resource/drugbank/drug/DB00016/identifier/pharmgkb/
xsdhhttp://www.w3.org/2001/XMLSchema#
n21http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00016
rdf:type
n3:Drug
n3:description
Human erythropoietin (recombinant), produced by CHO cells.
n3:dosage
n12:271B3F7D-363D-11E5-9242-09173F13E4C5 n12:271B3F7E-363D-11E5-9242-09173F13E4C5 n12:271B3F7F-363D-11E5-9242-09173F13E4C5 n12:271B3F80-363D-11E5-9242-09173F13E4C5 n12:271B3F81-363D-11E5-9242-09173F13E4C5 n12:271B3F82-363D-11E5-9242-09173F13E4C5 n12:271B3F83-363D-11E5-9242-09173F13E4C5 n12:271B3F84-363D-11E5-9242-09173F13E4C5 n12:271B3F85-363D-11E5-9242-09173F13E4C5 n12:271B3F86-363D-11E5-9242-09173F13E4C5 n12:271B3F87-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:indication
For treatment of anemia (from renal transplants or certain HIV treatment)
owl:sameAs
n15:DB00016 n20:DB00016
dcterms:title
Epoetin alfa
adms:identifier
n8:P01588 n9:X02158 n10:55513-126-10 n11:DB00016 n16:Epoetin_alfa n19:PA10072
n3:mechanismOfAction
Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.
n3:packager
n13:271B3F65-363D-11E5-9242-09173F13E4C5 n13:271B3F66-363D-11E5-9242-09173F13E4C5 n13:271B3F64-363D-11E5-9242-09173F13E4C5 n13:271B3F69-363D-11E5-9242-09173F13E4C5 n13:271B3F6A-363D-11E5-9242-09173F13E4C5 n13:271B3F67-363D-11E5-9242-09173F13E4C5 n13:271B3F68-363D-11E5-9242-09173F13E4C5
n3:patent
n26:1339047
n3:synonym
Erythropoietin precursor
n21:hasAHFSCode
n22:20-16-00
n23:hasConcept
n24:M0028770
foaf:page
n18:epoetin.htm n25:epoetin-alfa.html
n3:Molecular-Formula
n5:271B3F8B-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n5:271B3F8A-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
113427-24-0
n3:category
n3:clearance
* 20.2 +/- 15.9 mL/h/kg [150 Units/kg SC TIW, Week 1 when anemic cancer patients were receiving chemotherapy] * 23.6 +/- 9.5 mL/h/kg [150 Units/kg SC TIW, Week 3 when anemic cancer patients were not receiving chemotherapy] * 9.2 +/- 4.7 mL/h/kg [40,000 Units/kg SC TIW, Week 1 when anemic cancer patients were receiving chemotherapy] * 13.9 +/- 7.6 mL/h/kg [40,000 Units/kg SC TIW, Week 3 when anemic cancer patients were not receiving chemotherapy]
n3:containedIn
n6:271B3F6B-363D-11E5-9242-09173F13E4C5 n6:271B3F6E-363D-11E5-9242-09173F13E4C5 n6:271B3F6F-363D-11E5-9242-09173F13E4C5 n6:271B3F6C-363D-11E5-9242-09173F13E4C5 n6:271B3F6D-363D-11E5-9242-09173F13E4C5 n6:271B3F72-363D-11E5-9242-09173F13E4C5 n6:271B3F73-363D-11E5-9242-09173F13E4C5 n6:271B3F70-363D-11E5-9242-09173F13E4C5 n6:271B3F71-363D-11E5-9242-09173F13E4C5 n6:271B3F76-363D-11E5-9242-09173F13E4C5 n6:271B3F77-363D-11E5-9242-09173F13E4C5 n6:271B3F74-363D-11E5-9242-09173F13E4C5 n6:271B3F75-363D-11E5-9242-09173F13E4C5 n6:271B3F7A-363D-11E5-9242-09173F13E4C5 n6:271B3F7B-363D-11E5-9242-09173F13E4C5 n6:271B3F78-363D-11E5-9242-09173F13E4C5 n6:271B3F79-363D-11E5-9242-09173F13E4C5 n6:271B3F7C-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n5:271B3F89-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n5:271B3F88-363D-11E5-9242-09173F13E4C5