. "Alteplase"@en . . " "@en . . "Tissue-type plasminogen activator precursor"@en . . . "Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells"@en . . "t-PA"@en . "105857-23-6"@en . "Humans and other mammals"@en . . "t-plasminogen activator"@en . "approved"@en . . . . . . . . . "Alteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. "@en . . . "tPA"@en . . . . . . . . "For management of acute myocardial infarction, acute ischemic strok and for lysis of acute pulmonary emboli"@en . . . .