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Namespace Prefixes

PrefixIRI
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Statements

Subject Item
n2:DB00009
rdf:type
n3:Drug
n3:description
Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells
n3:dosage
n23:271B3EF7-363D-11E5-9242-09173F13E4C5 n23:271B3EF8-363D-11E5-9242-09173F13E4C5 n23:271B3EF9-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:indication
For management of acute myocardial infarction, acute ischemic strok and for lysis of acute pulmonary emboli
owl:sameAs
n17:DB00009 n26:DB00009
dcterms:title
Alteplase
adms:identifier
n11:Alteplase n12:PA164776730 n14:P00750 n15:DB00009 n18:D02837 n19:L00153
n3:mechanismOfAction
Alteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.
n3:packager
n13:271B3EF3-363D-11E5-9242-09173F13E4C5
n3:synonym
Tissue-type plasminogen activator precursor t-PA t-plasminogen activator tPA
n8:hasAHFSCode
n9:20-12-20
n6:hasConcept
n7:M0016991
foaf:page
n22:alteplas.htm n25:alteplase.html
n3:Molecular-Formula
n4:271B3EFE-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B3EFD-363D-11E5-9242-09173F13E4C5
n8:hasATCCode
n24:B01AD02 n24:S01XA13
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
105857-23-6
n3:category
n3:containedIn
n20:271B3EF5-363D-11E5-9242-09173F13E4C5 n20:271B3EF6-363D-11E5-9242-09173F13E4C5 n20:271B3EF4-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n4:271B3EFB-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n4:271B3EFC-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B3EFA-363D-11E5-9242-09173F13E4C5