This HTML5 document contains 37 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n9http://www.rxlist.com/cgi/generic3/
n2http://linked.opendata.cz/resource/drugbank/drug/
n24http://linked.opendata.cz/resource/drugbank/drug/DB00008/identifier/uniprotkb/
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/drugbank/drug/DB00008/identifier/genbank/
n7http://linked.opendata.cz/resource/AHFS/
n23http://linked.opendata.cz/resource/drugbank/company/
foafhttp://xmlns.com/foaf/0.1/
n19http://linked.opendata.cz/resource/drugbank/drug/DB00008/identifier/wikipedia/
n14http://linked.opendata.cz/resource/drugbank/drug/DB00008/identifier/pharmgkb/
n11http://linked.opendata.cz/resource/drugbank/dosage/
n21http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n17http://linked.opendata.cz/resource/drugbank/drug/DB00008/identifier/drugbank/
n4http://linked.opendata.cz/resource/drugbank/patent/
n16http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n18http://www.drugs.com/cdi/
n10http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n22http://linked.opendata.cz/resource/atc/
n6http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00008
rdf:type
n3:Drug
n3:description
Human interferon 2a, is a covalent conjugate of recombinant alfa-2a interferon with a single branched bis-monomethoxy polyethylene glycol (PEG) chain. The PEG moiety is linked at a single site to the interferon alfa moiety via a stable amide bond to lysine. Peginterferon alfa-2a has an approximate molecular weight of 60,000 daltons. Interferon alfa-2a is produced using recombinant DNA technology in which a cloned human leukocyte interferon gene is inserted into and expressed in Escherichia coli. The resultant protein is 165 amino acids. The PEG strand protects the molecule in vivo from proteolytic breakdown, substantially increases its in vivo half-life, and reduces immunogenicity by wrapping around and physically hindering access to the protein portion of the molecule.
n3:dosage
n11:271B3EED-363D-11E5-9242-09173F13E4C5 n11:271B3EEE-363D-11E5-9242-09173F13E4C5 n11:271B3EEF-363D-11E5-9242-09173F13E4C5 n11:271B3EEC-363D-11E5-9242-09173F13E4C5
n3:group
investigational approved
n3:halfLife
Terminal half life is 80 hours (range 50 to 140 hours).
n3:indication
For treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma.
owl:sameAs
n16:DB00008 n21:DB00008
dcterms:title
Peginterferon alfa-2a
adms:identifier
n13:J00207 n14:PA164749390 n17:DB00008 n19:Peginterferon_alfa-2a n24:P01563
n3:mechanismOfAction
Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
n3:packager
n23:271B3EE8-363D-11E5-9242-09173F13E4C5 n23:271B3EE7-363D-11E5-9242-09173F13E4C5
n3:patent
n4:2203480 n4:2172664
n6:hasAHFSCode
n7:08-18-20
n3:foodInteraction
Recommended adequate hydration.
foaf:page
n9:pegasys.htm n18:peginterferon-alfa-2a.html
n3:Molecular-Weight
n10:271B3EF2-363D-11E5-9242-09173F13E4C5
n6:hasATCCode
n22:L03AB11
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
198153-51-4
n3:category
n3:containedIn
n5:271B3EE9-363D-11E5-9242-09173F13E4C5 n5:271B3EEA-363D-11E5-9242-09173F13E4C5 n5:271B3EEB-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n10:271B3EF1-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n10:271B3EF0-363D-11E5-9242-09173F13E4C5