. . . . . . . . . . . . . . . "Tumor necrosis factor receptor 2"@en . . . . "Tumor necrosis factor receptor type II"@en . "investigational"@en . "There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind to two TNF molecules, thereby effectively removing them from circulation."@en . . . . . . . . "102 +/- 30 hrs in individuals with rheumatoid arthritis and 68 hours in healthy adults"@en . "p80 TNF-alpha receptor"@en . "Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids"@en . . . . "185243-69-0"@en . . . . . . "Bioavailability following sub-Q administration is approximately 60%. Peak plasma concentrations achieved within 69 hours. "@en . "Tumor necrosis factor receptor superfamily member 1B precursor"@en . "CD120b"@en . . . "* 160 +/- 80 mL/hr [RA patients]"@en . "Humans and other mammals"@en . . " "@en . . "Timothy D. Osslund, Christi L. Clogston, Shon Lee Crampton, Randal B. Bass, \"Crystals of etanercept and methods of making thereof.\" U.S. Patent US07276477, issued October 02, 2007."@en . "approved"@en . . "TNF-R2"@en . . "For treatment of severe active rheumatoid arthritis in adults, severe juvenile idiopathic arthritis, ankylosing spondylitis, and severe plaque psoriasis."@en . "Etanercept"@en . . "p75"@en . "# http://www.genome.jp/dbget-bin/www_bget?D00742 #American Society of Health System Pharmacists, Inc., DynaMed [Internet]. Ipswich (MA): EBSCO Information Services. 1995. Etanercept; [updated 2014 Sept 24 cited 2014 Nov 11]. Available from http://web.b.ebscohost.com.login.ezproxy.library.ualberta.ca/dynamed/detail?vid=4&sid=eeea413d-1490-4efa-bf5d-71f40e1986a1%40sessionmgr111&hid=123&bdata=JnNpdGU9ZHluYW1lZC1saXZlJnNjb3BlPXNpdGU%3d#db=dme&AN=232781"@en . .