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Namespace Prefixes

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Statements

Subject Item
n2:DB00004
rdf:type
n5:Drug
n5:description
A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.
n5:dosage
n14:271B3EA7-363D-11E5-9242-09173F13E4C5
n5:generalReferences
# Turturro F: Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders. Expert Rev Anticancer Ther. 2007 Jan;7(1):11-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17187516 # Park M, Liu GT, Piltz-Seymour J, Wisda CL, Rook AH, Junkins-Hopkins JM, Nasta SD, Kim EJ: Vision loss following denileukin diftitox treatment: a case report of possible posterior ischemic optic neuropathy. Leuk Lymphoma. 2007 Apr;48(4):808-11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17454642
n5:group
investigational approved
n5:halfLife
70-80 min
n5:indication
For treatment of cutaneous T-cell lymphoma
owl:sameAs
n10:DB00004 n21:DB00004
dcterms:title
Denileukin diftitox
adms:identifier
n4:V01536 n18:PA164750594 n19:Denileukin_diftitox n22:P00587 n23:62856-603-01 n24:DB00004
n5:mechanismOfAction
Denileukin diftitox binds to the high-affinity IL-2 receptor complex. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. The diphtheria toxin associated with Ontak then selectively kills the IL-2 bearing cells.
n5:packager
n20:271B3EA3-363D-11E5-9242-09173F13E4C5 n20:271B3EA4-363D-11E5-9242-09173F13E4C5 n20:271B3EA5-363D-11E5-9242-09173F13E4C5
n5:synonym
NAD(+--diphthamide ADP- ribosyltransferase) DT Diphtheria toxin precursor
n5:volumeOfDistribution
* 0.06 to 0.09 L/kg
n11:hasConcept
n12:M0292631
foaf:page
n8:denileukin.htm n13:denileukin-diftitox.html
n5:Molecular-Formula
n6:271B3EAB-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B3EAA-363D-11E5-9242-09173F13E4C5
n16:hasATCCode
n17:L01XX29
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
173146-27-5
n5:category
n5:clearance
* 0.6 - 2.0 mL/min/kg [Lymphoma]
n5:containedIn
n25:271B3EA6-363D-11E5-9242-09173F13E4C5
n5:Hydrophobicity
n6:271B3EA8-363D-11E5-9242-09173F13E4C5
n5:Isoelectric-Point
n6:271B3EA9-363D-11E5-9242-09173F13E4C5