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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F14%3A00431597%21RIV15-GA0-67985823
rdf:type
skos:Concept n17:Vysledek
dcterms:description
We demonstrate that methoctramine high affinity binding to the M2 receptors involves simultaneous interaction with both the orthosteric binding site and the allosteric binding site located between the second and third extracellular loops. Lysine 523 in the third extracellular loop of the M3 receptors forms a hydrogen bond with glutamate 219 of the second extracellular loop that hinders methoctramine binding to the allosteric site at this receptor subtype and results in low affinity of M3 receptor for methoctramine We demonstrate that methoctramine high affinity binding to the M2 receptors involves simultaneous interaction with both the orthosteric binding site and the allosteric binding site located between the second and third extracellular loops. Lysine 523 in the third extracellular loop of the M3 receptors forms a hydrogen bond with glutamate 219 of the second extracellular loop that hinders methoctramine binding to the allosteric site at this receptor subtype and results in low affinity of M3 receptor for methoctramine
dcterms:title
Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors
skos:prefLabel
Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors
skos:notation
RIV/67985823:_____/14:00431597!RIV15-GA0-67985823
n3:aktivita
n12:Z n12:P n12:I
n3:aktivity
I, P(GA305/09/0681), P(GAP304/12/0259), Z(AV0Z50110509)
n3:cisloPeriodika
2
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n4:6487890 n4:4299124 n4:8826897 n4:8398984
n3:druhVysledku
n16:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
30294
n3:idVysledku
RIV/67985823:_____/14:00431597
n3:jazykVysledku
n19:eng
n3:klicovaSlova
muscarinic receptors; selectivity; methoctramine; allosteric; FRET
n3:klicoveSlovo
n6:muscarinic%20receptors n6:selectivity n6:allosteric n6:FRET n6:methoctramine
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[7D46B1C2A7CC]
n3:nazevZdroje
Molecular Pharmacology
n3:obor
n9:ED
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:projekt
n15:GAP304%2F12%2F0259 n15:GA305%2F09%2F0681
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
86
n3:tvurceVysledku
Doležal, Vladimír Randáková, Alena El-Fakahany, E. E. Jakubík, Jan Zimčík, Pavel Fuksová, Květoslava
n3:wos
000339267500006
n3:zamer
n10:AV0Z50110509
s:issn
0026-895X
s:numberOfPages
13
n8:doi
10.1124/mol.114.093310