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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10285285%21RIV15-MSM-11110___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.ejphar.2014.05.057
dcterms:description
Lobeline is a plant alkaloid known to interact with cholinergic system. The effect of lobeline on neuronal alpha 3 beta 4 receptors expressed in COS cells and muscle embryonic alpha beta gamma delta receptors naturally expressed in TE671 cells was studied using a patch clamp technique. Our results show that lobeline inhibited responses to acetylcholine in human embryonic muscle nicotinic receptor in a pseudo noncompetitive manner. The responses of rat neuronal alpha 3 beta 4 receptors to a low concentration of acetylcholine were potentiated by a mixed occupation mechanism that corresponds to %22competitive potentiation%22. This potentiation turned into voltage dependent inhibition for alpha 3 beta 4 receptors was activated by a high concentration of acetylcholine. Lobeline is a plant alkaloid known to interact with cholinergic system. The effect of lobeline on neuronal alpha 3 beta 4 receptors expressed in COS cells and muscle embryonic alpha beta gamma delta receptors naturally expressed in TE671 cells was studied using a patch clamp technique. Our results show that lobeline inhibited responses to acetylcholine in human embryonic muscle nicotinic receptor in a pseudo noncompetitive manner. The responses of rat neuronal alpha 3 beta 4 receptors to a low concentration of acetylcholine were potentiated by a mixed occupation mechanism that corresponds to %22competitive potentiation%22. This potentiation turned into voltage dependent inhibition for alpha 3 beta 4 receptors was activated by a high concentration of acetylcholine.
dcterms:title
Different effects of lobeline on neuronal and muscle nicotinic receptors Different effects of lobeline on neuronal and muscle nicotinic receptors
skos:prefLabel
Different effects of lobeline on neuronal and muscle nicotinic receptors Different effects of lobeline on neuronal and muscle nicotinic receptors
skos:notation
RIV/00216208:11110/14:10285285!RIV15-MSM-11110___
n3:aktivita
n9:P n9:I
n3:aktivity
I, P(GA202/09/0806), P(GBP304/12/G069), P(IAA500110905)
n3:cisloPeriodika
June
n3:dodaniDat
n16:2015
n3:domaciTvurceVysledku
n10:8057230
n3:druhVysledku
n4:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
11456
n3:idVysledku
RIV/00216208:11110/14:10285285
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Lobeline; Embryonic muscle nicotinic receptor; Neuronal nicotinic receptor alpha3beta4
n3:klicoveSlovo
n8:Neuronal%20nicotinic%20receptor%20alpha3beta4 n8:Lobeline n8:Embryonic%20muscle%20nicotinic%20receptor
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[2508F55A3774]
n3:nazevZdroje
European Journal of Pharmacology
n3:obor
n18:ED
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:projekt
n13:GBP304%2F12%2FG069 n13:GA202%2F09%2F0806 n13:IAA500110905
n3:rokUplatneniVysledku
n16:2014
n3:svazekPeriodika
738
n3:tvurceVysledku
Skřenková, Kristýna Kaniakova, Martina Vyskočil, František Krusek, Jan Adámek, Svatopluk
n3:wos
000339998000044
s:issn
0014-2999
s:numberOfPages
8
n5:doi
10.1016/j.ejphar.2014.05.057
n17:organizacniJednotka
11110