"1"^^ . . . . . "0"^^ . "V\u00FDvoj nov\u00FDch metod pro sledov\u00E1n\u00ED genotoxick\u00FDch vliv\u016F \u017Eivotn\u00EDho prost\u0159ed\u00ED a mutagenity farmaceuticky vyu\u017Eiteln\u00FDch l\u00E1tek." . . "0"^^ . "2"^^ . . "TA03011057" . . "0"^^ . . . "2013-01-01+01:00"^^ . . . . "DNA damage caused by irradiation, chemical compounds and different metabolites often leads to irreversible mutations affecting human health. Accumulation of mutations during life of an individual leads to serious health risks including cancer and degenerative illnesses. The aim of the project is to develop and commercialize more sensitive methods for detection of DNA damage, i.e. genotoxicity, using reporter systems in cell lines, transgenic animals and their primary cells and to design new methodology in genotoxicity."@en . . "Development of new methods to analyze enviromental genotoxic stress and mutagenicity of potential pharmaceutical compounds."@en . "Po\u0161kozen\u00ED DNA zp\u016Fsobovan\u00E9 z\u00E1\u0159en\u00EDm, chemick\u00FDmi l\u00E1tkami i r\u016Fzn\u00FDmi metabolity \u010Dasto vede k nevratn\u00FDm mutac\u00EDm ovliv\u0148uj\u00EDc\u00ED lidsk\u00E9 zdrav\u00ED. Akumulace mutac\u00ED b\u011Bhem \u017Eivota jedince m\u016F\u017Ee m\u00EDt za n\u00E1sledek vznik spole\u010Densky z\u00E1va\u017En\u00FDch chorob, nap\u0159\u00EDklad zhoubn\u00E9 bujen\u00ED nebo degenerativn\u00ED nemoci. C\u00EDlem projektu je vyvinout a aplikovat citliv\u011Bj\u0161\u00ED metody umo\u017E\u0148uj\u00EDc\u00ED detekci a studium po\u0161kozen\u00ED DNA, tj. genotoxicity, pomoc\u00ED komplexn\u00EDch report\u00E9rov\u00FDch syst\u00E9m\u016F v bun\u011B\u010Dn\u00FDch lini\u00EDch, v transgenn\u00EDch zv\u00ED\u0159atech a z nich izolovan\u00FDch prim\u00E1rn\u00EDch bu\u0148k\u00E1ch a navrhnout nov\u00E9 metodick\u00E9 postupy v\u00FDzkumu genotoxicity." . . . "http://www.isvav.cz/projectDetail.do?rowId=TA03011057"^^ . . "DNA damage- transgenic mouse model- reporter- expression- genotoxic stress"@en . "2015-05-05+02:00"^^ . . . "2016-12-31+01:00"^^ . "2014-04-09+02:00"^^ . .