. . "2011-01-01+01:00"^^ . . . "TA01010781" . . "0"^^ . "2015-05-05+02:00"^^ . "Drug formulation development Photodynamic therapy of tumors Liposomal gel drug formulations Industrial microfludization"@en . . . . . . "We will focus gathered opinion of partners to develop industrial microfludization to prepare liposomal gel form drug formulation for hydrophobic hydroxy-aluminum phthalocyanine, already patented in its laboratory form for photodynamic therapy of tumors in dermatology, head and neck cancer and for colorectal carcinoma. In the first stage semi-industrial scale of first non=sterile and later sterile production will be developed and resulting preparations will be tested by experimental photodynamic therapy of human tumors xenotransplanted to nude mice while in the later stage full mature industrial professional production based on the Good Manufacture Practice procedures and quality controls will be developed. Resulting formulations will be not only tested but also described in Drug Master File for application of clinical testing in the National authority."@en . "1"^^ . . "2"^^ . "http://www.isvav.cz/projectDetail.do?rowId=TA01010781"^^ . "Pr\u016Fmyslov\u00E1 mikrofludizace liposom\u00E1ln\u00EDch a hydrof\u00F3bn\u00EDch l\u00E9kov\u00FDch forem" . . . "5"^^ . . "Navrhovan\u00FD projekt bude soust\u0159edit dosavadn\u00ED znalosti a zku\u0161enosti partner\u016F do experiment\u00E1ln\u00EDho v\u00FDvoje pr\u016Fmyslov\u00E9 p\u0159\u00EDpravy gelov\u00E9 liposom\u00E1ln\u00ED l\u00E9kov\u00E9 formy ftalocyaninu hydroxyhlinit\u00E9ho pro fotodynamickou terapii zhoubn\u00FDch n\u00E1dor\u016F, a to v za\u0159\u00EDzen\u00EDch firmy Wake, spol. s r.o., pobo\u010Dce v Rokycanech, kde byly zbudov\u00E1ny nov\u00E9 \u010Dist\u00E9 prostory spl\u0148uj\u00EDc\u00ED v\u0161echny p\u0159\u00EDslu\u0161n\u00E9 normy a akreditace St\u00E1tn\u00EDho \u00FAstavu pro kontrolu l\u00E9\u010Div (S\u00DAKL). Po optimalizovan\u00E9m experiment\u00E1ln\u00EDm v\u00FDvoji bude seps\u00E1n tzv. Drug Master File a bude pod\u00E1na \u017E\u00E1dost u S\u00DAKL o klinick\u00E1 testov\u00E1n\u00ED a registraci \u00FA\u010Dinn\u00E9 l\u00E1tky a jej\u00ED l\u00E9kov\u00E9 formy jako l\u00E9\u010Diva." . "5"^^ . "Industrial microfluidization of liposomal and hydrophobic drug formulations"@en . "2016-12-31+01:00"^^ . . . . . "2014-04-25+02:00"^^ . .