"2014-03-14+01:00"^^ . . "methamphetamine, psychostimulants, drug addiction, rat, sensorimotor development, maternal behavior, locomotion, Open field, cognition, learning and memory, Morris water maze, self-administration, gene analysis"@en . . . "GA14-03708S" . . . . "Metamfetamin (MA) je droga \u010Dasto zneu\u017E\u00EDvan\u00E1 t\u011Bhotn\u00FDmi \u017Eenami z\u00E1visl\u00FDmi na drog\u00E1ch a je sou\u010Dasn\u011B nej\u010Dast\u011Bji u\u017E\u00EDvanou drogou v \u010Cesk\u00E9 republice. Tato droga proch\u00E1z\u00ED snadno placent\u00E1rn\u00ED bari\u00E9rou do organismu plodu a m\u016F\u017Ee tak negativn\u011B ovliv\u0148ovat nejen matku, ale i prenat\u00E1ln\u00ED v\u00FDvoj jej\u00EDho potomstva. P\u0159esto, \u017Ee byla opublikov\u00E1na \u0159ada studi\u00ED ukazuj\u00EDc\u00EDch negativn\u00ED \u00FA\u010Dinky MA na potomky drogov\u011B z\u00E1visl\u00FDch matek, nen\u00ED zn\u00E1mo, kter\u00E9 obdob\u00ED t\u011Bhotenstv\u00ED je t\u00EDm nejkriti\u010Dt\u011Bj\u0161\u00EDm. Ur\u010Den\u00ED tohoto obdob\u00ED by bylo v\u00FDznamn\u00FDm zji\u0161t\u011Bn\u00EDm pro p\u0159\u00EDpadn\u00E9 vysazen\u00ED drog u t\u011Bhotn\u00FDch \u017Een z\u00E1visl\u00FDch na MA. V r\u00E1mci pl\u00E1novan\u00E9ho v\u00FDzkumn\u00E9ho projektu budou zji\u0161\u0165ov\u00E1ny \u00FA\u010Dinky prenat\u00E1ln\u00ED aplikace MA na potkan\u00ED matky a kr\u00E1tkodob\u00E9, pop\u0159. dlouhodob\u00E9 \u00FA\u010Dinky na jejich potomstvo. V\u00FDvojov\u00E1 obdob\u00ED (prenat\u00E1ln\u00ED a \u010Dasn\u011B postnat\u00E1ln\u00ED) u laboratorn\u00EDho potkana, rozd\u011Bl\u00EDme tak, aby p\u0159ibli\u017En\u011B odpov\u00EDdala trimestr\u016Fm prenat\u00E1ln\u00EDho obdob\u00ED u \u010Dlov\u011Bka. D\u00E1le budeme zji\u0161\u0165ovat, zda jsou ml\u00E1\u010Fata prenat\u00E1ln\u011B exponovan\u00E1 MA v\u00EDce citliv\u00E1 k t\u00E9\u017Ee droze po jej\u00EDm jednor\u00E1zov\u00E9m pod\u00E1n\u00ED a zda mechanismy p\u016Fsoben\u00ED prenat\u00E1ln\u00ED expozice MA mohou b\u00FDt i na genetick\u00E9 \u00FArovni." . " self-administration" . " learning and memory" . " maternal behavior" . . " Open field" . " cognition" . . . " locomotion" . "Determination of critical developmental period for methamphetamine effects in rats"@en . " Morris water maze" . " sensorimotor development" . "http://www.isvav.cz/projectDetail.do?rowId=GA14-03708S"^^ . . "2016-12-31+01:00"^^ . "0"^^ . . . "Methamphetamine (MA) is a frequently abused drug in pregnant drug-abusing women and is the most commonly used illicit drug in the Czech Republic. This drug passes through the placenta easily and can impair not only the mother but also the development of the offspring. Although many studies showed impairing effects of maternal MA injection on the offspring, it is not known which pregnancy period is the most critical. Determination of this period would be an important finding for the possible discontinuation of drug abuse in pregnant women addicted to MA. Within the planned project the effects of prenatal MA exposure will be examined in rat mothers and short- and long-term effects on their progeny. Developmental period (prenatal and early postnatal) in rats will be divided to approximately match the human prenatal trimesters. We will also determine whether the animals prenatally exposed to MA are more sensitive to the same drug and whether the mechanisms of effect may be genetic."@en . " psychostimulants" . "Urcen\u00ED kritick\u00E9 v\u00FDvojov\u00E9 periody pro \u00FAcinky metamfetaminu u laboratorn\u00EDho potkana" . "0"^^ . "2"^^ . "2015-04-23+02:00"^^ . "2"^^ . "1"^^ . "methamphetamine" . " drug addiction" . . . . . " rat" . . . "2014-01-01+01:00"^^ .