"Predikce ruptury v\u00FDdut\u011B b\u0159i\u0161n\u00ED aorty na z\u00E1klad\u011B v\u00FDpo\u010Dtov\u00E9ho modelov\u00E1n\u00ED" . . "aortic aneurysm" . . "0"^^ . . . . " hyperelastic material" . "2013-02-01+01:00"^^ . "1"^^ . " intraluminal thrombus" . . "2014-04-23+02:00"^^ . . "1"^^ . . "The project aims at improvement of description of mechanical properties of tissues in patient-specific computational models of abdominal aortic aneurysm (AAA) used in rupture prediction. The project deals with experimental measurements of mechanical properties of intraluminal thrombus (ILT), testing of the AAA wall under biaxial stress conditions and histological evaluation of orientation of collagen fibres in the wall. Application of the acquired data in AAA stress-strain analyses comprehends non-linear poroelastic constitutive model of ILT, incl. dependence of its parameters on the thickness and deformation of the ILT, multilayer models of the AAA wall, its unloaded geometry and residual stresses, accounting for stress concentration on the branch arteries and evaluation of the orientation of collagen fibres. For prediction of AAA rupture the rupture risk index will be used, which enables one to describe better the probable rupture location than maximum von Mises stress by including the local reduction of the ultimate stress or its direction dependency."@en . "Projekt je zam\u011B\u0159en na zlep\u0161en\u00ED popisu mechanick\u00FDch vlastnost\u00ED tk\u00E1n\u00ED v individu\u00E1ln\u00EDch v\u00FDpo\u010Dtov\u00FDch modelech aneurysmatu abdomin\u00E1ln\u00ED aorty (AAA) pacienta pou\u017E\u00EDvan\u00FDch k predikci ruptury. Experiment\u00E1ln\u00ED \u010D\u00E1st projektu se krom\u011B m\u011B\u0159en\u00ED mechanick\u00FDch vlastnost\u00ED intralumin\u00E1ln\u00EDho trombu (ILT) bude v\u011Bnovat zkou\u0161k\u00E1m st\u011Bny AAA ve dvouos\u00E9 napjatosti (do 3 hod. po odebr\u00E1n\u00ED) a histologick\u00E9mu vyhodnocov\u00E1n\u00ED orientace kolagenn\u00EDch vl\u00E1ken ve st\u011Bn\u011B. Vyu\u017Eit\u00ED z\u00EDskan\u00FDch poznatk\u016F k deforma\u010Dn\u011B-nap\u011B\u0165ov\u00E9 anal\u00FDze AAA zahrnuje pou\u017Eit\u00ED neline\u00E1rn\u00EDho poroelastick\u00E9ho konstitutivn\u00EDho modelu ILT, v\u010Detn\u011B z\u00E1vislosti jeho parametr\u016F na tlou\u0161\u0165ce a deformaci ILT, d\u00E1le v\u00EDcevrstv\u00E9 konstitutivn\u00ED modely st\u011Bny AAA, zohledn\u011Bn\u00ED jeho nezat\u00ED\u017Een\u00E9 geometrie a zbytkov\u00E9 napjatosti, zahrnut\u00ED koncentrace nap\u011Bt\u00ED na odbo\u010Duj\u00EDc\u00EDch tepn\u00E1ch a zhodnocen\u00ED v\u00FDznamu orientace kolagenn\u00EDch vl\u00E1ken. Pro predikci poru\u0161en\u00ED AAA budou anal\u00FDzy vyu\u017E\u00EDvat rozlo\u017Een\u00ED indexu rizika poru\u0161en\u00ED, co\u017E oproti metod\u011B maxim\u00E1ln\u00EDch nap\u011Bt\u00ED umo\u017E\u0148uje l\u00E9pe popsat m\u00EDsto pravd\u011Bpodobn\u00E9ho poru\u0161en\u00ED se zahrnut\u00EDm lok\u00E1ln\u00EDho sni\u017Eov\u00E1n\u00ED pevnosti st\u011Bny nebo jej\u00ED sm\u011Brov\u00E9 z\u00E1vislosti." . . . . . "2015-04-23+02:00"^^ . "GA13-16304S" . "6"^^ . . "6"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=GA13-16304S"^^ . . " rupture risk index" . "aortic aneurysm, hyperelastic material, intraluminal thrombus, rupture risk index, collagen fibre"@en . "Prediction of rupture of abdominal aortic aneurysm on the basis of computational modelling"@en . . "2015-12-31+01:00"^^ . .