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Statements

Subject Item
n2:7E11026
rdf:type
n16:Projekt
rdfs:seeAlso
http://www.isvav.cz/projectDetail.do?rowId=7E11026
dcterms:description
Dynamic information about biomolecular processes in living cells is important for fundamental understanding of cellular functions, which is one of the primary targets of molecular-cell biology with important applications to pharmacology. However for further progress in this field, and this specifically for monitoring genomic processes, there is immense need for developing sensing and detection techniquesthat can operate with sufficientsubmicroscopic resolution inside the living cells and bringing real-time information about local biomolecular interactions. The present proposal makes a further, large step towards integration of forefront nanotechnology, chemistry and molecular biology expertise with a common goal of studying intracellular processes in cells on nanoscale, which is the objective of this call. The aim of the DINAMO project is to develop the nanodiamond particle (NDP) non-invasive label free nanotechnology platform for real-time monitoring (1) of living cells modified by oncogenic impact, (2) of the kinetics of gene-assisted processes in the cell. Based on the development work of DINAMO, we propose to apply luminiscent and single spin detection techniques for real-time monitoring of biomoleuar processes in cells. Dynamic information about biomolecular processes in living cells is important for fundamental understanding of cellular functions, which is one of the primary targets of molecular-cell biology with important applications to pharmacology. However for further progress in this field, and this specifically for monitoring genomic processes, there is immense need for developing sensing and detection techniquesthat can operate with sufficientsubmicroscopic resolution inside the living cells and bringing real-time information about local biomolecular interactions. The present proposal makes a further, large step towards integration of forefront nanotechnology, chemistry and molecular biology expertise with a common goal of studying intracellular processes in cells on nanoscale, which is the objective of this call. The aim of the DINAMO project is to develop the nanodiamond particle (NDP) non-invasive label free nanotechnology platform for real-time monitoring (1) of living cells modified by oncogenic impact, (2) of the kinetics of gene-assisted processes in the cell. Based on the development work of DINAMO, we propose to apply luminiscent and single spin detection techniques for real-time monitoring of biomoleuar processes in cells.
dcterms:title
Development of nanodiamond intracellular nanoprobes for oncogen transformation dynamics in living cells Development of nanodiamond intracellular nanoprobes for oncogen transformation dynamics in living cells
skos:notation
7E11026
n3:aktivita
n19:7E
n3:celkovaStatniPodpora
n4:celkovaStatniPodpora
n3:celkoveNaklady
n4:celkoveNaklady
n3:datumDodatniDoRIV
2014-06-30+02:00
n3:druhSouteze
n22:RP
n3:duvernostUdaju
n9:S
n3:fazeProjektu
n13:100705764
n3:hlavniObor
n6:FD
n3:hodnoceniProjektu
n21:U
n3:kategorie
n20:ZV
n3:klicovaSlova
nanodiamonds, cell biology, gene probe/reader, gene therapeutics, cancer stem cells, saccharide vector, antibody protein vector, gene-targeting, miRNA, biological imaging
n3:partnetrHlavni
n17:ico%3A61388971
n3:pocetKoordinujicichPrijemcu
0
n3:pocetPrijemcu
1
n3:pocetSpoluPrijemcu
0
n3:pocetVysledkuRIV
0
n3:pocetZverejnenychVysledkuVRIV
0
n3:posledniUvolneniVMinulemRoce
2013-03-27+01:00
n3:prideleniPodpory
n5:13595%2F2011+%E2%80%93+321
n3:sberDatUcastniciPoslednihoRoku
n10:2013
n3:sberDatUdajeProjZameru
n10:2014
n3:statusZobrazovaneFaze
n14:DUU
n3:typPojektu
n18:P
n3:ukonceniReseni
2013-04-30+02:00
n3:vedlejsiObor
n6:EC n6:CF
n3:zahajeniReseni
2011-01-01+01:00
n3:zhodnoceni+vysledku+projektu+dodavatelem
Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider. Hodnocení výsledků řešení ministerstvo neprovádí, neboť podmínkou podpory je, že uchazeč byl vybrán mezinárodním poskytovatelem v souladu s pravidly příslušného programu. Projekt je hodnocen až po jeho schválení mezinárodním poskytovatelem.
n3:zivotniCyklusProjektu
n11:ZBKU
n3:vyzva
n15:FP7-KBBE-2009-3
n3:klicoveSlovo
saccharide vector nanodiamonds cancer stem cells gene probe/reader gene therapeutics miRNA gene-targeting antibody protein vector cell biology