"2010-04-06+02:00"^^ . "2005-08-01+02:00"^^ . " atherosclerosis" . . . . . . . "5"^^ . "5"^^ . . . "1"^^ . . " vitamine E" . "The development and application of new biotechnological methods to study relationship of phenotypes, genotypes and response to statin therapy upon lipoprotein metabolism"@en . "1"^^ . . "Statins are administered to a wide range of individuals on an empirical basis. Investigation of the phenotype and genotype influences on treatment response will allow a more tailored use of these drugs. The development and application of new biotechnological methods to study relationship of phenotypes, genotypes and response to statin therapy upon lipoprotein metabolism will be used: i) distribution of statins and its metabolites in serum lipoprotein and cell membranes, ii) vitamin E content in serum and cell membranes, iii) lipoperoxidation formation and antioxidant consumption"@en . . "0"^^ . "Byla vypracov\u00E1na p\u016Fvodn\u00ED UPLC/MS/MS metodika pro stanoven\u00ED hladin statin\u016F simvastatinu a atorvastatinu i jejich metabolit\u016F v biologick\u00E9m materi\u00E1lu. V\u00FDsledky povedou ke zv\u00FD\u0161en\u00ED efektivity terapie a racionalizaci n\u00E1klad\u016F na zdravotn\u00ED p\u00E9\u010Di."@cs . . . " lipoperoxidation" . "An original UPLC/MS/MS method for the determination of levels of statins simvastatin and atorvastatin and their metabolites in biological material was developed. The results will improve pharmacotherapy effectiveness and racionalize health care costs."@en . " phenotype" . "1A8689" . "diagnostic methods; statins; lipoperoxidation; dyslipidaemia; HPLC; atherosclerosis; vitamine E; phenotype, genotype"@en . "diagnostic methods" . " HPLC" . "2008-12-31+01:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=1A8689"^^ . "V\u00FDvoj a vyu\u017Eit\u00ED nov\u00FDch biotechnologick\u00FDch metod ke studiu vazby fenotypu, genotypu a \u00FA\u010Dinku l\u00E9\u010Dby statiny na metabolismus lipoprotein\u016F" . . " statins" . "2008-03-05+01:00"^^ . . " dyslipidaemia" . . . "Statiny jsou \u0161iroce pou\u017E\u00EDvan\u00E1 l\u00E9\u010Diva pod\u00E1van\u00E1 pacient\u016Fm \u010Dasto na empirick\u00E9 b\u00E1zi. Zkoum\u00E1n\u00ED vlivu fenotypu a genotypu na jejich l\u00E9\u010Debn\u00E9 \u00FA\u010Dinky umo\u017En\u00ED efektivn\u011Bj\u0161\u00ED pou\u017E\u00EDv\u00E1n\u00ED t\u011Bchto l\u00E9\u010Div. V\u00FDvoj a aplikace nov\u00FDch biotechnologick\u00FDch a diagnostick\u00FDch metod ke sledov\u00E1n\u00ED vztah\u016F mezi fenotypem, genotypem a odezvou na l\u00E9\u010Dbu statiny ve vztahu k metabolismu lipoprotein\u016F bude vyu\u017Eito pro: i) objasn\u011Bn\u00ED distribuce statin\u016F a jejich metabolit\u016F v jednotliv\u00FDch lipoproteinov\u00FDch frakc\u00EDch a bun\u011B\u010Dn\u00FDch membr\u00E1n\u00E1ch ii) sledov\u00E1n\u00ED obsahu vitaminu E v s\u00E9ru a bun\u011B\u010Dn\u00FDch membr\u00E1n\u00E1ch iii) sledov\u00E1n\u00ED lipoperoxidace a spot\u0159eby antioxidant\u016F" .