. . . . . " clonal analysis" . "N. meningitidis; molecular biology; clonal analysis; hypervirulent; MLST; MLEE; vaccine; vaccination strategy"@en . "2007-03-01+01:00"^^ . . "7"^^ . . "7"^^ . . . . "0"^^ . "The work has these real outputs: creationn of the proposal of new vaccination strategy against invasive mengokok illness, molecular characterization of clinical isolates Neisseria meningitidis was performed."@en . "1"^^ . "Study of hypervirulent complexes of Neisseria meningitidis by methods of molecular biology and possibility of their prevention in the Czech Republic by vaccination"@en . . "1A8688" . "Klon\u00E1ln\u00ED studium N. meningitidis metodami molekul\u00E1rn\u00ED biologie umo\u017En\u00ED definovat pod\u00EDl hypervirulentn\u00EDch komplex\u016F na sou\u010Dasn\u00E9m v\u00FDskytu invazivn\u00EDho meningokokov\u00E9ho onemocn\u011Bn\u00ED v \u010Cesk\u00E9 republice a ur\u010Dit trend v\u00FDvoje. Ke klon\u00E1ln\u00EDmu studiu bude pou\u017Eita zejm\u00E9na metoda multilokusov\u00E9 sekven\u010Dn\u00ED typizace (MLST). Z\u00EDskan\u00E1 data budou p\u0159edkl\u00E1d\u00E1na k ov\u011B\u0159en\u00ED a k registraci v celosv\u011Btov\u00E9 MLST datab\u00E1zi. Zji\u0161t\u011Bn\u00ED pod\u00EDlu hypervirulentn\u00EDch komplex\u016F na v\u00FDskytu invazivn\u00EDho meningokokov\u00E9ho onemocn\u011Bn\u00ED umo\u017En\u00ED zp\u0159esnit doporu\u010Denou vakcina\u010Dn\u00ED strategii v \u010Cesk\u00E9 republice. Poskytov\u00E1n\u00ED dat do celosv\u011Btov\u00E9 MLST datab\u00E1ze p\u0159isp\u011Bje k roz\u0161\u00ED\u0159en\u00ED znalost\u00ED pot\u0159ebn\u00FDch k v\u00FDvoji univerz\u00E1ln\u011B \u00FA\u010Dinn\u00E9 meningokokov\u00E9 vakc\u00EDny." . " molecular biology" . "2008-09-26+02:00"^^ . "0"^^ . . "Clonal analysis of N. meningitidis by the methods of molecular biology will enable definition of participation of hypervirulent complexes on actual morbidity of invasive meningococcal disease in the Czech Republic. Multilocus sequence typing (MLST) will be the method preferably used for clonal analysis in this project. The MLST data will be sent to the world-wide central MLST database for confirmation and registration. The definition of participation of hypervirulent complexes on actual morbidity of invasive meningococcal disease in the Czech Republic will enable to precise recommendation of vaccination strategy in the Czech Republic. Submission of Czech MLST data to the world-wide central MLST database will contribute to the knowledge which is necessary for the development of universally efficient meningococcal vaccine."@en . . . "http://www.isvav.cz/projectDetail.do?rowId=1A8688"^^ . "N. meningitidis" . " hypervirulent" . " MLEE" . . "2007-12-31+01:00"^^ . . "Studium hypervirulentn\u00EDch komplex\u016F Neisseria meningitidis metodami molekul\u00E1rn\u00ED biologie a mo\u017Enosti prevence jejich v\u00FDskytu v \u010Cesk\u00E9 republice vakcinac\u00ED" . . " vaccine" . . "2005-08-01+02:00"^^ . "Pr\u00E1ce m\u00E1 tyto re\u00E1ln\u00E9 v\u00FDstupy: vytvo\u0159en\u00ED n\u00E1vrhu nov\u00E9 vakcina\u010Dn\u00ED strategie proti invazivn\u00EDmu meningokokov\u00E9mu onemocn\u011Bn\u00ED, byla provedena molekul\u00E1rn\u00ED charakterizace klinick\u00FDch izol\u00E1t\u016F Neisseria meningitidis."@cs . " MLST" .