. "This is a multicenter, randomized study evaluating the safety and efficacy of autologous mononuclear bone marrow cell transplantation in 90 patients with acute myocardial infarction. The myocardial function, perfusion, and metabolism in the infarcted area will be compared in patients implanted with a high (100 millions) or standard (10 millions) dose of cells and in the control group not randomized for cell transplantation. The parameters evaluated will be obtained before and 3 months after the cell transplantation. The main aim of our project is to determine the effect of the number of implanted cells on the magnitude of myocardial regeneration and to assure whether the number of implated cells should be adjusted to the infarct size."@en . . . "1A8676" . . . "U 90 nemocn\u00FDch s akutn\u00EDm infarktem myokardu a nevratn\u00FDm po\u0161kozen\u00EDm funkce infarktov\u00E9ho lo\u017Eiska bude hodnocena \u00FA\u010Dinnost a bezpe\u010Dnosti autologn\u00ED transplantace mononukle\u00E1rn\u00EDch d\u0159e\u0148ov\u00FDch bun\u011Bk podan\u00FDch intrakoron\u00E1rn\u011B 6-9 den po vzniku infarktu. Bude srovn\u00E1na funkce, perfuze a metabolismus infarktov\u00E9ho lo\u017Eiska p\u0159ed a za 3 m\u011Bs\u00EDce po implantaci vysok\u00E9 (100 mili\u00F3n\u016F) \u010Di standardn\u00ED (10 mili\u00F3n\u016F) d\u00E1vky d\u0159e\u0148ov\u00FDch bun\u011Bk. V\u00FDsledky budou srovn\u00E1ny s kontroln\u00EDm souborem nel\u00E9\u010Den\u00FDm bun\u011B\u010Dnou transplantac\u00ED. Bude posouzen vliv po\u010Dtu implantovan\u00FDch bun\u011Bk na stupe\u0148 regenerace po\u0161kozen\u00E9ho myokardu. Bude ur\u010Deno, je-li t\u0159eba (a jak) p\u0159izp\u016Fsobit po\u010Det implantovan\u00FDch bun\u011Bk mase nevratn\u011B po\u0161kozen\u00E9ho myokardu." . "Intracoronary application of core cells is safe upon the use immediately afte the heart attract. Repeated attempts for intracoronary application of stem cells after few months can be accompanied by the serious troubles."@en . "acute myocardial infarction; cell transplantation; myocardial regeneration; stem cells"@en . " cell transplantation" . . "2008-09-26+02:00"^^ . . . . . "0"^^ . . . "acute myocardial infarction" . "1"^^ . "3"^^ . . . . . "8"^^ . "2007-12-31+01:00"^^ . "Autologous transplantation of bone marrow cells in patients with acute myocardial infarction. The effect of the number of transplanted cells on the reduction of infarct size"@en . "8"^^ . "http://www.isvav.cz/projectDetail.do?rowId=1A8676"^^ . "2007-03-01+01:00"^^ . "2005-08-01+02:00"^^ . "Autologn\u00ED transplantace d\u0159e\u0148ov\u00FDch bun\u011Bk u nemocn\u00FDch s akutn\u00EDm infarktem myokardu. Vliv po\u010Dtu transplantovan\u00FDch bun\u011Bk na redukci infarktov\u00E9ho lo\u017Eiska" . . "Intrakoron\u00E1rn\u00ED aplikace d\u0159e\u0148ov\u00FDch bun\u011Bk je bezpe\u010Dn\u00E1 p\u0159i pou\u017Eit\u00ED bezprost\u0159edn\u011B po infarktu.Opakovan\u00E9 pokusy o intrakoron\u00E1rn\u00ED aplikaci kmenov\u00FDch bun\u011Bk v odstupu n\u011Bkolika m\u011Bs\u00EDc\u016F v\u0161ak mohou prov\u00E1zet v\u00E1\u017En\u00E9 komplikace(\u010D\u00E1st studie,byla proto p\u0159ed\u010Dasn\u011B ukon\u010Dena)"@cs . . " myocardial regeneration" .