. " prevention" . . . . . "2007-03-02+01:00"^^ . "nephropathy; coronary; angiography; angioplasty; prevention; theophylline; contrast"@en . . . "In patients with elevated creatinine, administration of contrast can cause impairment of renal function. This project is based on hypothesis as follows: intravenous theophylline administration prior to invasive procedure can prevent renal impairment. Primary endpoint: statistically and clinically significant reduction of plasma creatinine increase at 24 and 48 hours after coronary angiography or angioplasty in active group /200 mg of theophylline prior to procedure/ in comparison with placebo group. Secondary endpoint: comparison of incidence of contrast induced nephropathy / increase of plasma creatinine level by 44.2 umol/l / in both study groups on condition that adequate hydratation of all patients is provided. Effective prevention of contrast media induced renal impairment could significantly decrease morbidity of patients with renal failure scheduled for transcatheter or surgical myocardial revascularisation."@en . "The importance of teofylinas a nephroprotective pharma before giving the contrast l\u00E1tka did not succeed. the study has shown the importance of the whole complex of measures which reduce the occurrence of contrast nephropathy"@en . . . "2008-09-26+02:00"^^ . . . . " coronary" . "nephropathy" . " angiography" . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=1A8652"^^ . . . "Pod\u00E1n\u00ED rentgenkontrastn\u00ED l\u00E1tky nemocn\u00FDm se zv\u00FD\u0161enou plazmatickou hladinou kreatininu vede a\u017E u 20% vy\u0161et\u0159en\u00FDch k po\u0161kozen\u00ED ledvin. Projekt vych\u00E1z\u00ED z hypot\u00E9zy, \u017Ee intraven\u00F3zn\u00EDm pod\u00E1n\u00EDm teofylinu bezprost\u0159edn\u011B p\u0159ed v\u00FDkonem lze po\u0161kozen\u00ED zabr\u00E1nit. Prim\u00E1rn\u00EDm endpointem je pr\u016Fkaz statisticky a klinicky v\u00FDznamn\u00E9ho sn\u00ED\u017Een\u00ED vzestupu plazmatick\u00E9ho kreatininu za 24 a 48 hodin po koronarografii nebo koron\u00E1rn\u00ED angioplastice v intervenovan\u00E9 v\u011Btvi (200 mg teofyl\u00EDnu preprocedur\u00E1ln\u011B) oproti v\u011Btvi placebov\u00E9. Sekund\u00E1rn\u00EDm endpointem je anal\u00FDza v\u00FDskytu kontrastem indikovan\u00E9 nefropatie v z\u00E1vislosti na preprocedur\u00E1ln\u00ED vypo\u010D\u00EDt\u00E1van\u00E9 hodnot\u011B kreatininov\u00E9 clearance p\u0159i d\u016Fsledn\u00E9 hydrataci v\u0161ech vy\u0161et\u0159ovan\u00FDch pacient\u016F. \u00DA\u010Dinn\u00E1 prevence po\u0161kozen\u00ED ledvin rentgenkontrastn\u00EDmi l\u00E1tkami m\u016F\u017Ee v\u00FDznamn\u011B sn\u00ED\u017Eit morbiditu nemocn\u00FDch s poruchou ren\u00E1ln\u00EDch funkc\u00ED, indikovan\u00FDch ke kat\u00E9trov\u00E9 nebo chirurgick\u00E9 revaskularizaci myokardu." . "2"^^ . . "0"^^ . "2"^^ . "0"^^ . . . "2005-08-01+02:00"^^ . " theophylline" . " angioplasty" . "1A8652" . . "V\u00FDznam teofyl\u00EDnu jako nefroprotektivn\u00EDho farmaka p\u0159ed pod\u00E1n\u00EDm kontrastn\u00ED l\u00E1tky se nepoda\u0159ilo prok\u00E1zat.Studie uk\u00E1zala v\u00FDznam cel\u00E9ho komplexu opat\u0159en\u00ED, kter\u00E1 sni\u017Euj\u00ED v\u00FDskyt kontrastov\u00E9 nefropatie."@cs . "2007-12-31+01:00"^^ . "Teofyl\u00EDn v prevenci kontrastem indukovan\u00E9 nefropatie, randomizovan\u00E1 studie" . "Theophyllin in prevention of contrast induced nephropathy, randomised trial"@en .