. " polycystic ovary syndrome" . "2009-12-31+01:00"^^ . "epilepsy; catamenial epilepsy; antiepileptic drugs; steroids; neuroactive steroids; neuroprotective steroids; polycystic ovary syndrome; steroid metabolism"@en . "2009-12-18+01:00"^^ . " catamenial epilepsy" . . . . "Relationships of steroid metabolism to the patogenesis and treatment of epilepsy"@en . . . " neuroprotective steroids" . . " steroids" . . " neuroactive steroids" . "Epilepsy is connected with disturbances in reproductive functions. Some antiepileptic drugs as the epilepsy status induce the development of reproductive endocrinopathies influencing at least the course of epilepsy. Some circulating steroids surpass the blood-brain barrier. They bind to intraculular receptors and, together with locally produced steroids, modulate also the ionotropic membrane receptors of neuronal cells influencing the neuronal activity. We will concentrate on the changes in steroid biosynhesis in patients with epilepsy after treatment with antiepileptic drugs in a complete metabolic pathway from pregnenolone sulfate and pregnenolone up to active hormones. We will follow the effect of antiepilptic drugs on steroidogenesis in the 5-en pathway as on their neuroprotective 7-hydroxy- metabolites, pregnane and androstane neuroactive steroids and the balance between free steroids and sulfates."@en . "2010-08-20+02:00"^^ . . . "Metabolismus steroid\u016F ve vztahu k patogenezi a terapii epilepsie" . "2005-08-01+02:00"^^ . . . "V\u00FDsledky p\u0159edm\u011Btn\u00E9ho projektu zahrnuj\u00ED dejm\u00E9na v\u00FDvoj nov\u00FDch senzitivn\u00EDch metod k detekci 69 steroidn\u00EDch metabolit\u016F. Tyto metodiky a stanoven\u00ED steroidn\u00EDch metabolit\u016F mohou potenci\u00E1ln\u011B p\u0159isp\u011Bt ke zlep\u0161en\u00ED diagn\u00F3zy nekter\u00FDch neurologick\u00FDch onemocn\u011Bn\u00ED."@cs . " antiepileptic drugs" . . . "0"^^ . . . . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=1A8649"^^ . "Epilepsie je spojena s poruchami v oblasti reproduktivn\u00ED endokrinologie. N\u011Bkter\u00E1 antiepileptick\u00E1 l\u00E9\u010Diva i samotn\u00E1 epilepsie z\u0159ejm\u011B indukuj\u00ED vznik reproduktivn\u00EDch endokrinopati\u00ED a ty mohou ovliv\u0148ovat p\u0159inejmen\u0161\u00EDm pr\u016Fb\u011Bh epilepsie. N\u011Bkter\u00E9 cirkuluj\u00EDc\u00ED steroidy p\u0159ekon\u00E1vaj\u00ED hematoencefalickou bari\u00E9ru. V mozku se v\u00E1\u017E\u00ED na intracelul\u00E1rn\u00ED receptory a s lok\u00E1ln\u011B produkovan\u00FDmi steroidy moduluj\u00ED i ionotropn\u00ED membr\u00E1nov\u00E9 receptory nervov\u00FDch bun\u011Bk. Mohou tak ovliv\u0148ovat nervovou aktivitu. Zam\u011B\u0159\u00EDme se na zm\u011Bny biosynt\u00E9zy steroid\u016F u pacient\u016F s epilepsi\u00ED (v\u010Detn\u011B katameni\u00E1ln\u00ED) po aplikaci r\u016Fzn\u00FDch skupin antiepileptick\u00FDch l\u00E9\u010Div v kompletn\u00ED metabolick\u00E9 cest\u011B od pregnenolonsulf\u00E1tu a pregnenolonu k hormon\u016Fm p\u016Fsob\u00EDc\u00EDm genomov\u011B i negenomov\u011B. Budeme sledovat \u00FA\u010Dinek antiepileptick\u00FDch l\u00E9\u010Div na synt\u00E9zu steroid\u016F v 5-en cest\u011B i jejich neuroprotektivn\u00EDch 7-hydroxylovan\u00FDch metabolit\u016F, pregnanov\u00FDch a androstanov\u00FDch neuroaktivn\u00EDch steroid\u016F, a na rovnov\u00E1hu mezi voln\u00FDmi a sulfatovan\u00FDmi steroidy." . "1"^^ . "3"^^ . . "epilepsy" . "The results of present project comprise mainly the development of sensitive techniques for detection of 69 steroids metabolites. These developments could potentionaly contribute to the improvement of diagnosis of particular neurological disorders."@en . "1A8649" . "3"^^ .