. "Neurosteroids - a risk factors of some brain diseases?"@en . . . "neurosteroids; brain; neoplasia; homocysteine; steroidogenic; enzyme; deuterium"@en . "V\u00FDsledkem je zaveden\u00ED metodiky stanoven\u00ED aktivity steroidn\u00ED sulfat\u00E1zy a sulfotransfer\u00E1zy ve tk\u00E1n\u00EDch. S pou\u017Eit\u00EDm uveden\u00E9 metodiky byly z\u00EDsk\u00E1ny prioritn\u00ED v\u00FDsledky na vzorc\u00EDch tk\u00E1n\u00ED mozku prim\u00E1t\u016F a tk\u00E1n\u00EDch mozkov\u00FDch tumor\u016F u lid\u00ED."@cs . "2007-12-31+01:00"^^ . . "2008-09-26+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=1A8637"^^ . " enzyme" . "1A8637" . . . . . "The main result of the project is introduction of new method of assessment of activity of steroid sulfatase and sulfotransferase in tissue samples."@en . . " steroidogenic" . "7"^^ . "7"^^ . "V subcelul\u00E1rn\u00EDch frakc\u00EDch z lidsk\u00FDch mozkov\u00FDch tk\u00E1n\u00ED z\u00EDskan\u00FDch p\u0159i nezbytn\u00FDch operac\u00EDch mozku budeme vy\u0161et\u0159ovat aktivity steroidogenn\u00EDch enzym\u016F (p\u0159edev\u0161\u00EDm sulfat\u00E1zy a sulfotransfer\u00E1zy). D\u00E1le budeme vy\u0161et\u0159ovat spektrum neurosteroid\u016F a aminothiol\u016F. Budeme zji\u0161\u0165ovat zda a jak se li\u0161\u00ED spektrum a koncentrace jednotliv\u00FDch neurosteroid\u016F a aminothiol\u016F v z\u00E1vislosti na typu onemocn\u011Bn\u00ED mozku." . . "2007-03-01+01:00"^^ . "2005-08-01+02:00"^^ . . . "neurosteroids" . " neoplasia" . " homocysteine" . . " brain" . . . "We will determine the activities of steroidogenic enzymes (mainly sulfatase and sulfotransferase) in human brain tumorous tissues obtained during necessary surgical operation. Moreover we will determine spectrum of neurosteroids and aminothiols. We will try to find the differences in the spectrum and concentrations of neurosteroids and aminothiols in dependance on the type of the brain disease."@en . . . "0"^^ . "1"^^ . . "1"^^ . "Neurosteroidy - rizikov\u00E9 faktory u vybran\u00FDch onemocn\u011Bn\u00ED mozku?" .