"http://www.isvav.cz/projectDetail.do?rowId=1A8632"^^ . "analgosedation; tramadol; developmental pharmacokinetics; pharmacodynamics; CYP2D6; pharmacogenetics; metabolism"@en . . " pharmacodynamics" . "2009-12-31+01:00"^^ . " developmental pharmacokinetics" . " CYP2D6" . . . "C\u00EDlem studie je objasnit zda je maturace biotransforma\u010Dn\u00EDch cest p\u0159\u00ED\u010Dinou variability farmakokinetick\u00FDch parametr\u016F tramadolu a popsat vliv genetick\u00E9ho polymorfizmu enzymu CYP2D6 na variabilitu farmakokinetiky l\u00E9\u010Diva v pr\u016Fb\u011Bhu v\u00FDvoje. Budeme z\u00E1rove\u0148 klinicky hodnotit \u00FA\u010Dinky l\u00E9\u010Diva b\u011Bhem l\u00E9\u010Dby i po jej\u00EDm skon\u010Den\u00ED a sledovat korelaci s farmakokinetick\u00FDmi parametry v jednotliv\u00FDch skupin\u00E1ch pacient\u016F. Do studie bude za\u0159azeno v optim\u00E1ln\u00EDm p\u0159\u00EDpad\u011B 240 d\u011Bt\u00ED, u kter\u00FDch je indikov\u00E1na analgosadace tramadolem. Subjekty budou hodnoceny ve skupin\u00E1ch podle v\u011Bku (nedono\u0161en\u00ED novorozenci, novorozenci, kojenci, star\u0161\u00ED d\u011Bti) a podle aktivity CYP2D6." . . "2009-12-18+01:00"^^ . "1A8632" . . . "2005-08-01+02:00"^^ . . . . . " tramadol" . . . . . "2010-08-20+02:00"^^ . . "The aim of the study is to describe if maturation of biotransformation pathways changes pharmacokinetic parameters of tramadol and wheather the genetic polymorphism of CYP2D6 influences this develpmental variability. We will also evaluate the clinical effects of the drug during therapy and after its discontinuation and corelate the clinical data with the pharmacokinetic parameters in separate groups of patients. Optimally, two hundred and forty children will be included into the study. The patients will be evaluated in groups with respect to their age and genotype of CYP2D6."@en . "3"^^ . . "analgosedation" . "0"^^ . . "3"^^ . "Developmental Pharmacokinetics and Pharmacogenetic Aspects of Analgesic Sedation by Tramadol in Newborns, Infants and Older Children Treated at the Intensive Care Unit"@en . "V\u00FDsledkem \u0159e\u0161en\u00ED projektu je zaveden\u00ED metodiky rutinn\u00EDho monitorov\u00E1n\u00ED \u00FA\u010Dinnosti analgezie, anal\u00FDzy genotypu CYP2D6 a dvou analytick\u00FDch metod (GC-MS a LC-MSMS) pro stereoselektivn\u00ED simult\u00E1nn\u00ED anal\u00FDzu enanciomer\u016F tramadolu a O-demethyltramadolu."@cs . "1"^^ . . "Main outcome of the project is development and implementation of routine monitoring of analgesic efficiacy, determination of CYP2D6 genotype and two analytic methods (GC-MS and LC-MSMS) for stereoselective determination of tramadol and O-demethyltramadol"@en . . " pharmacogenetics" . "V\u00FDvojov\u00E1 farmakokinetika a farmakogenetick\u00E9 aspekty analgosedace tramadolem u novorozenc\u016F, kojenc\u016F a star\u0161\u00EDch d\u011Bt\u00ED hospitalizovan\u00FDch na jednotce intenzivn\u00ED p\u00E9\u010De" . . "0"^^ .