"The studies on XME polymorphism and the disease progression, histology and chemotherapy and on the influence selected genetic polymorphisms XME might exhibit individuals or populations with higher risk of nonhereditary breast cancer."@en . "Polymorphisms of genes of xenobiotic metabolizing enzymes (XME) and their relation to incidence of non-hereditary breast cancer will be studied to identify risk individuals for more frequent and earlier examination to reveal early stages of cancer. Effects of polymorphisms of XME genes on metabolism of anticancer drugs will be studied by measuring their pharmacokinetics in plasma of patients treated for breast cancer. The aim is to find relation to success of treatment of recommend the change. Expression of ABC transporters, eliminate anticancer drugs from tumors as an important mechanism of multidrug resistance will be followed to uncover probable resistance to chemotherapy and to recommend the change of chemotherapy. The project is aimed at possibility to decrease advanced stages of breast cancer by screening of XME genetic polymorphisms as well as to contribute to improved chemotherapy in subjects with facilitated drug metabolism and transport from tumors."@en . " biotransformation" . " xenobiotics" . "breast cancer; xenobiotics; anticancer; pharmacokinetics; genetics; polymorphism; biotransformation; chemotherapy"@en . " anticancer" . "Pr\u00E1ce p\u0159isp\u011Bla k potvrzen\u00ED, \u017Ee vybran\u00E9 genetick\u00E9 polymofrismy XME mohou odhalit jedince \u010Di skupiny populace s vy\u0161\u0161\u00EDm rizikem neheredit\u00E1rn\u00ED rakoviny ml\u00E9\u010Dn\u00E9 \u017El\u00E1zy."@cs . " polymorphism" . "2007-08-08+02:00"^^ . . . . . . "http://www.isvav.cz/projectDetail.do?rowId=1A8248"^^ . . "1A8248" . "Budeme studovat polymorfismy gen\u016F biotransforma\u010Dn\u00EDch enzym\u016F xenobiotik (XME) a jejich vztah k incidenci neheredit\u00E1rn\u00ED rakoviny prsu. C\u00EDlem je vytipovat jedince pro detailn\u011Bj\u0161\u00ED a \u010Dast\u011Bj\u0161\u00ED %22klasick\u00E1%22 vy\u0161et\u0159en\u00ED k odhalen\u00ED \u010Dasn\u011Bj\u0161\u00ED stadi\u00ED rakoviny prsu. Budeme sledovat vliv polymorfism\u016F gen\u016F XME na metabolismus cytostatik studiem jejich farmakokinetiky v krevn\u00ED plasm\u011B pacient\u016F l\u00E9\u010Den\u00FDch na rakovinu prsu. C\u00EDlem je zjistit souvislost s \u00FAsp\u011Bchem chemoterapie, p\u0159\u00EDpadn\u011B navrhnout jinou l\u00E9\u010Dbu. Budeme zji\u0161\u0165ovat expresi ABC transporter\u016F, kter\u00E9 vylu\u010Duj\u00ED cytostatika z n\u00E1dor\u016F a p\u0159edstavuj\u00ED v\u00FDznamn\u00FD mechanismus mnoho\u010Detn\u00E9 resistence na l\u00E9ky (multidrug resistance, MDR).C\u00EDlem je odhalit pravd\u011Bpodobnou resistenci na chemoterapii a navrhnout jej\u00ED zm\u011Bnu. C\u00EDlem projektu je naj\u00EDt mo\u017Enost sn\u00ED\u017Eit vznik pokro\u010Dil\u00FDch stadi\u00ED rakoviny prsu pomoc\u00ED skr\u00EDninku polymorfismu gen\u016F XME a p\u0159isp\u011Bt k zv\u00FD\u0161en\u00ED \u00FAsp\u011B\u0161nost\u00ED chemoterapie u jedinc\u016F se zrychlen\u00FDm metabolismem cytostatik a jejich zv\u00FD\u0161en\u00FDm vylu\u010Dov\u00E1n\u00EDm z n\u00E1dor\u016F." . . "Influence of biotransformation and transport on incidence of breast cancer and effect of chemotherapy"@en . . . . "0"^^ . . . . . "1"^^ . "Vliv biotransformace a transportu na incidenci rakoviny prsu a \u00FA\u010Dinky chemoterapie" . . "1"^^ . " genetics" . "3"^^ . . "3"^^ . . . . "breast cancer" . . " pharmacokinetics" . .