. "2007-08-08+02:00"^^ . " mammary gland" . "STAT" . "STAT; JAK; SOCS; astroglioma; cancerogenesis; mammary gland; prostate gland; prognosis"@en . . "Poru\u0161en\u00ED sign\u00E1ln\u00EDch drah JAK/STAT a jejich inhibitor\u016F m\u016F\u017Ee b\u00FDt p\u0159\u00ED\u010Dinou selh\u00E1n\u00ED imunitn\u00EDho dozoru a m\u016F\u017Ee napom\u00E1hat p\u0159i vzniku a \u0161\u00ED\u0159en\u00ED r\u016Fzn\u00FDch n\u00E1dor\u016F, v\u010Detn\u011B karcinom\u016F prostaty, ml\u00E9\u010Dn\u00E9 \u017El\u00E1zy a astrogli\u00E1ln\u00EDch n\u00E1dor\u016F. C\u00EDlem je anal\u00FDza exprese protein\u016F rodiny STAT,JAK a jejich inhibitor\u016F SOCS u n\u00E1dor\u016F mozku, ml\u00E9\u010Dn\u00E9 \u017El\u00E1zy a prostaty a jejich korelace s prolifera\u010Dn\u00ED aktivitou, gradingem a expres\u00ED hormon\u00E1ln\u00EDch receptor\u016F \u010Di protein\u016F reguluj\u00EDc\u00EDch apopt\u00F3zu a bun\u011B\u010Dn\u00FD cyklus. P\u0159edpokl\u00E1d\u00E1me identifikaci nov\u00FDch prognostick\u00FDch a prediktivn\u00EDch znak\u016F u n\u00E1dor\u016F mozku, ml\u00E9\u010Dn\u00E9 \u017El\u00E1zy a prostaty." . . . "http://www.isvav.cz/projectDetail.do?rowId=1A8244"^^ . . "Disruption of signaling of JAK/STAT/SOCS may be the cause of failure of immune surveillance and may participate in development and invasion of various tumors, including carcinomas of prostate gland, breast and glial tumors of brain. The aim is analysis of expression of proteins JAK/STAT/SOCS in carcinomas of prostate gland, breast and in gliomas and its correlation with grading, expression of steroid receptors and proteins regulating apoptosis, proliferation and cell cycle. We suppose identification of new prognostic and predictive markers in glial tumors of brain and in carcinomas of breast and prostate gland."@en . . . . " JAK" . " prostate gland" . . . "Anal\u00FDza exprese protein\u016F STAT, JAK a SOCS v n\u00E1dorech mozku, ml\u00E9\u010Dn\u00E9 \u017El\u00E1zy a prostaty. Korelace s histologick\u00FDm obrazem, gradingem, expres\u00ED steroidn\u00EDch receptor\u016F a expres\u00ED protein\u016F reguluj\u00EDc\u00EDch bun\u011B\u010Dn\u00FD cyklus a apopt\u00F3zu" . . "1"^^ . . " astroglioma" . . "2"^^ . "0"^^ . . "Vy\u0161et\u0159en\u00ED sign\u00E1ln\u00ED dr\u00E1hy STAT/JAK a jej\u00EDch inhibitor\u016F v mozkov\u00FDch n\u00E1dorech a v karcinomu prostaty a mmy p\u0159sp\u00EDv\u00E1 k pozn\u00E1n\u00ED k pozn\u00E1n\u00ED prolifera\u010Dn\u00EDch i apoptogenn\u00EDch proces\u016F v n\u00E1dorov\u00E9 bu\u0148ce a m\u016F\u017Ee posl\u00E9ze up\u0159esnit diagnosu, prognosu a v budoucnu i terapii."@cs . "2"^^ . . "0"^^ . "Analysis of expression of STAT, JAK and SOCS in glial tumors of brain and in carcinomas of breast and prostate gland. Correlation with grading, expression of steroid receptors and expression of proteins regulating cell cycle and apoptosis."@en . " SOCS" . "1A8244" . . . . . . " cancerogenesis" . "The study of signal pathway STAT/JAK and its inhibitors in cerebral tumours, prostate and breast carcinoma contributes to understand the process of proliferation and apoptosis of tumor cells and subsequently it can lead to more accurate diagnosis."@en . .