"Zaveden\u00ED metody real-time RT-PCR ke kvantitativn\u00EDmu stanoven\u00ED 5 marker\u016F melanomovan\u00FDch bun\u011Bk v krvi.U 20 z 65 nemocn\u00FDch smal.mel IIA-IIIB s klin.progres\u00ED-elevace aspo\u0148 1 z marker\u016F a\u017E v 9m\u011Bs.p\u0159edstihu-perspektivn\u00ED metoda monitorov\u00E1n\u00ED progrese melanomu."@cs . . . . "9"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=1A8243"^^ . "Real-time RT-PCR; Melanoma; Tumor marker; Tyrosinase; Adjuvant therapy"@en . . "9"^^ . . . . . . . . " Tyrosinase" . "0"^^ . "1"^^ . "Real-time RT-PCR" . "2007-08-08+02:00"^^ . . . " Tumor marker" . " Melanoma" . "0"^^ . "Establishment of real-time PCR quantitative meth.for detection of5 melanoma cells markers in peripheral blood.In20 out of 60 pat. with malignant melonoma(IIa-IIIB) with clinical progression elevation of at least 1 of mark.was detected up 9 m in advance."@en . . . "1A8243" . . "Quantitative detection of circulating melanoma cells by real-time RT-PCR in patients treated for malignant melanoma"@en . "Kvantitativn\u00ED detekce cirkuluj\u00EDc\u00EDch melanomov\u00FDch bun\u011Bk pomoc\u00ED real-time RT-PCR u pacient\u016F l\u00E9\u010Den\u00FDch pro malign\u00ED melanom" . . "The aim of the study is quantitative detection of circulating tumor cells in patients treated for melanoma with adjuvant therapy. A quantitative multimarker real-time RT-PCR assay will assess frequency of melanoma-specific markers from peripheral blood. Such a sensitive early-warning assay would be a particularly useful surrogate for determining which patients should be selected for more aggressive treatment protocols before the onset of clinically detectable metastatic disease."@en . . "C\u00EDlem studie je kvantitativn\u00ED detekce cirkuluj\u00EDc\u00EDch n\u00E1dorov\u00FDch bun\u011Bk u pacient\u016F s melanomem l\u00E9\u010Den\u00FDch adjuvantn\u00ED terapi\u00ED. Pomoc\u00ED kvantitativn\u00ED multimarkerov\u00E9 RT-PCR v re\u00E1ln\u00E9m \u010Dase se zjist\u00ED mno\u017Estv\u00ED melanomov\u00FDch marker\u016F v perifern\u00ED krvi. V\u00FDhodou tohoto vy\u0161et\u0159en\u00ED je tak\u00E9 vysok\u00E1 sensitivita, kter\u00E1 umo\u017E\u0148uje v\u010Das reagovat na to, kter\u00E9mu pacientovi je t\u0159eba nasadit agresivn\u011Bj\u0161\u00ED l\u00E9\u010Dbu je\u0161t\u011B p\u0159ed vznikem klinicky manifestn\u00EDch metast\u00E1z." .