. " cytotoxicity" . "Modelling of potentially antimycobacterial active compounds"@en . . "Byly p\u0159ipraveny deriv\u00E1ty benzoxazolu,pyrazinamidu,isoniazidu a salicylamidu jako nov\u00E1 potenci\u00E1ln\u00ED antituberkolotika. Je pops\u00E1n vztah nmezi chemickou strukturou a biologickou aktivitou studovan\u00FDch l\u00E1tek."@cs . . . . "Synt\u00E9za nov\u00FDch potenci\u00E1ln\u011B antimykobakteri\u00E1ln\u011B/antifung\u00E1ln\u011B aktivn\u00EDch slou\u010Denin je aktu\u00E1ln\u00ED vzhledem ke zvy\u0161uj\u00EDc\u00EDmu se v\u00FDskytu tuberkul\u00F3zy (MDR-TB, latentn\u00ED kmeny) a mykotick\u00FDch onemocn\u011Bn\u00ED (aspergil\u00F3zy) jak v celosv\u011Btov\u00E9mu, tak v n\u00E1rodn\u00EDm m\u011B\u0159\u00EDtku. C\u00EDlem projektu je spojen\u00ED na\u0161eho syntetick\u00E9ho potenci\u00E1lu s kvalitn\u00ED testovac\u00ED z\u00E1kladnou, tvo\u0159enou antituberkulotick\u00FDm, antifung\u00E1ln\u00EDm, p\u0159\u00EDp. cytotoxick\u00FDm hodnocen\u00EDm. V\u00FDsledkem projektu bude vyhodnocen\u00ED vztah\u016F mezi strukturou a biologick\u00FDm \u00FA\u010Dinkem v n\u011Bkolika s\u00E9ri\u00EDch nov\u011B p\u0159ipraven\u00FDch antituberkulotik, stanoven\u00ED fyzik\u00E1ln\u011B-chemick\u00FDch parametr\u016F a modelov\u00E1n\u00ED prodrug forem." . . "Tuberculosis is the leading cause of death in the world from a single infectious disease. The problem arising due to MDR-TB requires the development of new agents that have better or a unique mechanism of action, different from the currently used. Attachment of our synthetic potential and SAR knowledge with the good antimycobacterial, antifungal, resp. cytoxicity evaluation is the aim of the project. Complete described series of novel prospective antitubercular/antifungal compounds will be the result of our project."@en . " antitubercular" . . . . . "1A8238" . "modeling" . . "21"^^ . "21"^^ . "Derivates of benzoxazolu,pyrazinamidu,isoniazidu and salicylamidu as a new potential antituberculotic drugs were prepared. Chemical structure-biological activity relatinships among the evaluated compounds are described."@en . " synthesis" . . . "modeling; antitubercular; antifungal; cytotoxicity; synthesis; lipophilicity"@en . " antifungal" . . . . "1"^^ . "2007-08-08+02:00"^^ . "0"^^ . . "0"^^ . "Modelov\u00E1n\u00ED potenci\u00E1ln\u011B antimykobakteri\u00E1ln\u011B aktivn\u00EDch l\u00E1tek" . . . "http://www.isvav.cz/projectDetail.do?rowId=1A8238"^^ .