. . "1A8237" . . . . . . "The most frequent aberrations ( del p53,p16, Rb1, 1p36, 19q13, ampl EGFR, +7,-10) were evaluated in gliomas using molecular cytogenetics. Finding of abberations typical for high grade astrocytoma in low grade tumors was sign of shorter aurvival."@en . "Molekul\u00E1rn\u011B cytogenetick\u00E1 anal\u00FDza bun\u011Bk mozkov\u00FDch tumor\u016F a jej\u00ED p\u0159\u00EDnos pro diagnostiku a l\u00E9\u010Dbu" . . "MOLECULAR CYTOGENETIC ANALYSIS OF BRAIN TUMOUR CELLS AND ITS CONTRIBUTION TO DIAGNOSIS AND TREATMENT."@en . . . " molecular cytogenetics" . " I-FISH" . . . . . . . "brain tumours; chromosomal aberration; molecular cytogenetics; I-FISH; prognostic factors; instability of genome"@en . "2007-08-08+02:00"^^ . "4"^^ . . "Metodami molekul\u00E1rn\u00ED cytogenetiky byly hled\u00E1ny nej\u010Dast\u011Bj\u0161\u00ED aberace ( del p53,p16,Rb1, 1p36 a 19q13, ampl EGFR, + 7, -10) v gliomech. U n\u00E1dor\u016F n\u00EDzk\u00E9ho stupn\u011B n\u00E1lez aberac\u00ED typick\u00FDch pro astrocytomy vysok\u00E9ho stupn\u011B signalizoval krat\u0161\u00ED p\u0159e\u017Eit\u00ED."@cs . "4"^^ . . "1"^^ . "1"^^ . " chromosomal aberration" . . "brain tumours" . "Molecular cytogenetic study of large cohort of patients with brain tumours. Identification of the most frequent chromosomal changes and evaluation of significance of single and cumulative cytogenetic aberrations for course and prognosis of the disease. To establish prognostic model of brain tumours on the basis of genetic aberrations. Stratification of the patients into prognostic groups with possibilities to optimalize the efficiency of the treatment."@en . "http://www.isvav.cz/projectDetail.do?rowId=1A8237"^^ . "0"^^ . . "Molekul\u00E1rn\u011B cytogenetick\u00E1 studie signifikantn\u00ED skupiny nemocn\u00FDch s mozkov\u00FDmi tumory. Sledov\u00E1n\u00ED nej\u010Dast\u011Bj\u0161\u00EDch chromosomov\u00FDch aberac\u00ED a zhodnocen\u00ED v\u00FDznamu jednotliv\u00FDch i kumulovan\u00FDch cytogenetick\u00FDch odchylek pro pr\u016Fb\u011Bh a progn\u00F3zu onemocn\u011Bn\u00ED. Vytvo\u0159en\u00ED prognostick\u00E9ho modelu na z\u00E1klad\u011B genetick\u00FDch aberac\u00ED. Stratifikace nemocn\u00FDch do prognostick\u00FDch skupin s mo\u017Enost\u00ED n\u00E1sledn\u00E9 optimalizace l\u00E9\u010Debn\u00E9ho p\u0159\u00EDstupu." . . " prognostic factors" .