_:b725835 . _:b725835 . _:b725837 . _:b725836 . _:b725837 . . . _:b725835 . "Pharmacologic Substance"^^ . _:b725836 . _:b725835 . "697525"^^ . "697525"^^ . "C96227"^^ . "cFMS Tyrosine Kinase Inhibitor ARRY-382"^^ . _:b725836 . "cFMS Tyrosine Kinase Inhibitor ARRY-382"^^ . _:b725836 . "cFMS Tyrosine Kinase Inhibitor ARRY-382PTNCI" . _:b725837 . _:b725837 . "CL429011"^^ . "A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.NCI" . "ARRY-382CNNCI" .