"AMG337CNNCI" . . "c-Met Inhibitor AMG 337PTNCI" . . "Pharmacologic Substance"^^ . "C95203"^^ . "690935"^^ . "690935"^^ . "c-Met Inhibitor AMG 337"^^ . "An orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.NCI" . "c-Met Inhibitor AMG 337"^^ . "AMG 337CNNCI" . "CL426693"^^ .