"Warfarin"^^ . "A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).NCI-GLOSS" . . _:b723544 . "A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.NCI" . "Warfarin"^^ . _:b723542 . "C945"^^ . _:b723543 . "Athrombin-KBRNCI" . _:b723544 . "1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanoneSNNCI" . . "59813"^^ . "warfarinPTNCI-GLOSSCDR0000045249" . "Compound 42SYDTPNSC0059813" . "5Q7ZVV76EI"^^ . _:b723542 . "FDA"^^ . _:b723543 . "Pulmonary embolism and thromboembolic disorders, treatment and prophylaxis; Venous thrombosis, prophylaxis and treatment"^^ . "Compound 42BRNCI" . "WarfarinSYDTPNSC0059813" . "3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarinSYDTPNSC0059813" . "Warfarin"^^ . . _:b723542 . _:b723544 . . "3-(Alpha-acetonylbenzyl)-4-hydroxycoumarinSNNCI" . _:b723543 . _:b723544 . "WARF compound 42SYDTPNSC0059813" . . "CHEBI:10033"^^ . _:b723542 . "39740"^^ . "C19H16O4"^^ . "4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-oneSNNCI" . "Chemotherapy-induced INR changes; Thrombosis prophylaxis"^^ . "Co-RaxBRNCI" . . "RodexBRNCI" . _:b723543 . "39740"^^ . . "Organic Chemical"^^ . . "Pharmacologic Substance"^^ . "WarfarinPTNCI" . "WARF Compound 42BRNCI" . "3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarinSNNCI" . "C0043031"^^ . "3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarinSYDTPNSC0059813" . "WARFARINPTFDA5Q7ZVV76EI" . "81-81-2"^^ .