"Recombinant Tumor Necrosis Factor-AlphaPTNCI" . "Amino Acid, Peptide, or Protein"^^ . _:b719387 . "Pharmacologic Substance"^^ . "43225"^^ . _:b719387 . "C913"^^ . _:b792751 _:b719387 . "697068"^^ . "43225"^^ . "Recombinant Tumor Necrosis Factor-Alpha"^^ . "TNF-AlphaSYNCI" . "C1522669"^^ . _:b719388 . _:b729488 _:b792751 . _:b719389 . "308079-78-9"^^ . "TNFAABNCI" . "Therapeutic_Tumor_Necrosis_Factor-Alpha"^^ . _:b719389 . "X2C8Z061MB"^^ . _:b719388 . _:b640578 . _:b792753 . _:b719387 . "CachectinSYNCI" . . "Serum glycoprotein produced by activated macrophages and other mammalian mononuclear leukocytes. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share two receptors.MSH2002_06_01" . _:b792751 _:b792752 . _:b640578 . _:b792752 _:b719388 . _:b719388 . "Tumor Necrosis Factor (TNF-alpha)SYNCI" . _:b792752 _:b792753 . . _:b792753 _:b719389 . _:b729488 . . "Recombinant Tumor Necrosis Factor-Alpha"^^ . _:b719389 . "FDA"^^ . "TUMOR NECROSIS FACTOR-.ALPHA. HUMAN (SOLUBLE FORM)PTFDAX2C8Z061MB" . "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-alpha with antineoplastic properties. Tumor necrosis factor-alpha binds to and activates "death receptors" on the cell surface, resulting in apoptosis and cell death by the p53-independent extrinsic pathway. This agent also disrupts tumor vascularization. (NCI04)NCI" . _:b640578 _:b729488 .