. "671819"^^ . . "CL421475"^^ . "A polymeric nanoparticle (PNP) formulation containing the taxane docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase, preventing cell proliferation. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Compared to docetaxel alone, the PNP formulation may enhance stability and improve delivery.NCI" . "Docetaxel-PNP"^^ . "Docetaxel-PNPPTNCI" . "Docetaxel-PNP"^^ . "C91087"^^ . "Pharmacologic Substance"^^ . "671819"^^ . "Organic Chemical"^^ .