"INCB028060CNNCI" . "An orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. c-Met inhibitor INCB028060 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.NCI" . "C90564"^^ . . "c-Met Inhibitor INCB028060PTNCI" . "666907"^^ . . "Pharmacologic Substance"^^ . "666907"^^ . "c-Met Inhibitor INCB028060"^^ . "c-Met Inhibitor INCB028060"^^ . "CL416248"^^ .