"Protein Stabilized Liposomal Docetaxel NanoparticlesPTNCI" . "Protein Stabilized Liposomal Docetaxel Nanoparticles"^^ . . "ATI-1123CNNCI" . "C90534"^^ . "Protein Stabilized Liposomal Docetaxel Nanoparticles"^^ . . "CL413616"^^ . "663670"^^ . "Pharmacologic Substance"^^ . "663670"^^ . "A formulation containing protein-stabilized liposome nanoparticles encapsulating the poorly water-soluble, second-generation taxane analog docetaxel with antineoplastic activity. Docetaxel binds to and stabilizes the beta-tubulin subunit, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Compared to the use of toxic carriers to increase solubilization of docetaxel, protein-stabilized liposomal docetaxel improves drug solubility while avoiding carrier-associated toxicity.NCI" .