. "C0142923"^^ . . "An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation.NCI" . . "681583"^^ . . "C87346"^^ . "HIW548RQ3W"^^ . "Sodium SelenitePTNCI" . "SODIUM SELENITEPTFDAHIW548RQ3W" . "Selenious Acid Disodium SaltSYNCI" . "Sodium Selenite"^^ . "681583"^^ . "2Na.O3Se"^^ . . "Disodium Selenium TrioxideSYNCI" . "Sodium Selenite"^^ . "CHEBI:48843"^^ . "FDA"^^ . "10102-18-8"^^ . "Selenious Acid, Sodium Salt (1:2)SYNCI" . "Pharmacologic Substance"^^ .