"Human NQO1*2 allele is located in the vicinity of 16q22.1 and is approximately 17 kb in length. The NQO1 *2 allele has a C609T substitution in the cDNA, which encodes NAD(P)H dehydrogenase [quinone] 1*2 protein that results in the amino acid change P187S. The NQO1*2 protein has both diminished catalytic activity and altered degradation by the ubiquitin-proteasomal system. Expression of this allele is associated with increased risk of benzene hematotoxicity, asthma and leukemias and decreased breast cancer survival.NCI" . "NQO1*2 Allele"^^ . _:b695734 . _:b695735 . "C2698418"^^ . "Increased risk of leukemia has been associated with the NQO1*2 allele and diminished NQO1 activity. Childhood leukemia (particularly with MLL fusions), adult leukemia (ALL, AML particularly with translocations or inversions) and secondary leukemias and myelodysplasias as a result of chemotherapy have been associated with the NQO1*2 polymorphism. Cells and tissues carrying the homozygous NQO1*2 allele have no detectable NQO1 activity and at best, trace levels of NQO1 protein. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)"^^ . _:b695736 . _:b695734 . "125860"^^ . "C78134"^^ . "rs1800566"^^ . "NQO1 p. Pro187SerSYNCI" . _:b695735 . _:b695736 . _:b695737 . "NAD(P)H Dehydrogenase, Quinone 1*2 AlleleSYNCI" . "NQO1*2SYNCI" . _:b695736 . . _:b695737 . "NQO1 c. 609 C-T AlleleSYNCI" . . _:b695737 . "NM_000903"^^ . "Gene or Genome"^^ . "NQO1_2_Allele"^^ . _:b695736 . "NQO1*2 Allele"^^ . _:b695734 . _:b695734 . "1728"^^ . _:b695735 . _:b695737 . "NQO1 p. P187SSYNCI" . _:b695735 . "NQO1 C609TSYNCI" . "NQO1*2 AllelePTNCI" .