"Propylthiouracil"^^ . . "CHEBI:8502"^^ . "6-Propyl-2-thiouracilSYDTPNSC0070461" . . "FDA"^^ . "C0033511"^^ . "70461"^^ . "PropylthiouracilPTNCI" . "6-Propyl-2-ThiouracilSYNCI" . "C781"^^ . "PropylthiouracilSYDTPNSC0070461" . "39288"^^ . . "51-52-5"^^ . "C7H10N2OS"^^ . "Propylthiouracil"^^ . . "A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.NCI" . "39288"^^ . "Pharmacologic Substance"^^ . "721M9407IY"^^ . "Propylthiouracil"^^ . . "Nucleic Acid, Nucleoside, or Nucleotide"^^ . "A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)MSH2002_06_01" . . "PROPYLTHIOURACILPTFDA721M9407IY" .