<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://www.w3.org/2000/01/rdf-schema#label>	"Epothilone KOS-1584"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106>	"Pharmacologic Substance"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#code>	"C77892"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P329>	"594152"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://linked.opendata.cz/ontology/mesh/hasConcept>	<http://linked.opendata.cz/resource/mesh/concept/M0408630> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90>	"<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Epothilone KOS-1584</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P207>	"C1099968"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P330>	"594152"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90>	"<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>KOS-1584</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106>	"Organic Chemical"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P108>	"Epothilone KOS-1584"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90>	"<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>9,10-Didehydroepothilone D</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://www.w3.org/1999/02/22-rdf-syntax-ns#type>	<http://www.w3.org/2002/07/owl#Class> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P97>	"<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>A second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>" .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P366>	"Epothilone_KOS-1584"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77892>	<http://www.w3.org/2000/01/rdf-schema#subClassOf>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25974> .