"Oral_Milataxel"^^ . . "Pharmacologic Substance"^^ . "TL139CNNCI" . "Oral Milataxel"^^ . "C77880"^^ . . "An orally bioavailable taxane with potential antineoplastic activity. Upon oral administration, milataxel and its major active metabolite M-10 bind to and stabilize tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, milataxel appears to be a poor substrate for the multidrug resistance (MDR) membrane-associated P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors.NCI" . "Oral Milataxel"^^ . "Oral MilataxelPTNCI" . "TL-00139CNNCI" . "Organic Chemical"^^ . "597742"^^ . "CL387339"^^ . "597742"^^ .