. "167354-41-8"^^ . "AB5K82X98Y"^^ . . "Organic Chemical"^^ . "Zosuquidar"^^ . "ZOSUQUIDARPTFDAAB5K82X98Y" . "C76198"^^ . "FDA"^^ . "Zosuquidar"^^ . "ZosuquidarPTNCI" . "Pharmacologic Substance"^^ . "Zosuquidar"^^ . . "A difluorocyclopropyl quinoline. Zosuquidar binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents.NCI" . "(R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanolSNNCI" . . "C32H31F2N3O2"^^ . "C2700337"^^ .