"Pharmacologic Substance"^^ . "42405"^^ . "CHEBI:8069"^^ . "PHENOBARBITALPTFDAYQE403BP4D" . . "YQE403BP4D"^^ . "A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates.NCI-GLOSS" . . . "C0031412"^^ . . "FDA"^^ . "128143"^^ . . . "A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.NCI" . "9848"^^ . "PhenobarbitalPTDCP00018" . "PHENOABNCI" . "Phenobarbital"^^ . . "50-06-6"^^ . "C12H12N2O3"^^ . . "42405"^^ . "Phenobarbital"^^ . "phenobarbitalPTNCI-GLOSSCDR0000045470" . "Phenobarbital"^^ . "PhenobarbitalPTNCI" . "5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrioneSNNCI" . "Organic Chemical"^^ . "C739"^^ . "Epilepsy"^^ . .