"Ischemia, cerebral and peripheral"^^ . "PapaverinePTNCI" . "PavabidBRNCI" . "136630"^^ . "PapaverinePTDCP30427" . . "Papaverine"^^ . "An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.MSH2002_06_01" . "Papaverine"^^ . . "PavatymBRNCI" . "Pharmacologic Substance"^^ . "Papaverine"^^ . . "C726"^^ . "C0030350"^^ . "39545"^^ . "Organic Chemical"^^ . "CHEBI:28241"^^ . "CerespanBRNCI" . "RobaxapapBRNCI" . . "PapaverineSYDTPNSC0136630" . "PavacapFBNCI" . "39545"^^ . "DAA13NKG2Q"^^ . "58-74-2"^^ . . "C20H21NO4"^^ . "PAPAVERINEPTFDADAA13NKG2Q" . . "CerebidFBNCI" . "FDA"^^ . . "An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. As a direct-acting smooth muscle relaxant, papaverine is not closely related to the other opium alkaloids in structure or pharmacological actions; its mechanism of action may involve the non-selective inhibition of phosphodiesterases and direct inhibition of calcium channels. This agent also exhibits antiviral activity against respiratory syncytial virus, cytomegalovirus, and HIV. (NCI04)NCI" . .