. "Taxane-Site Binding AgentSYNCI" . . "Chemical Viewed Functionally"^^ . "Any of a class of anti-mitotic compounds that bind to the taxane site of the beta-tubulin subunit, a region described as a binding pocket located within the middle domain and corresponding to an approximate residue sequence of 217-231. Specifically, these agents bind to a cysteine residue within the pocket, which is also the binding site for GTP. Agents binding at the taxane site promote the polymerization of dimers to form a very rigid and stable microtubule structure which is not readily disassembled. By interfering with microtubule dynamics these agents inhibit the normal turnover process essential during mitosis, thereby causing cell-cycle arrest and/or apoptosis.NCI" . "Taxane-Pocket Binding Agent"^^ . "Taxane-Pocket Binding AgentPTNCI" . "Taxane-Pocket Binding Agent"^^ . "C67437"^^ . "C1883268"^^ . "Taxane-Site_Binding_Agent"^^ .