"MithracineFBNCI" . "A-2371SYDTPNSC0024559" . "C52H76O24"^^ . . "41738"^^ . "plicamycinPTNCI-GLOSSCDR0000463729" . "18378-89-7"^^ . "A-2371CNNCI" . "PA-144CNNCI" . . "24559"^^ . "Aureolic acidSYDTPNSC0024559" . "C0026234"^^ . "CHEBI:31856"^^ . "Plicamycin"^^ . "MithracinPTNCI-GLOSSCDR0000484118" . "Organic Chemical"^^ . . "MithracinBRNCI" . "MithracinSYDTPNSC0024559" . "MTHABNCI" . "An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)NCI" . "PLICAMYCINPTFDANIJ123W41V" . "A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic.NCI-GLOSS" . "Aureolic acidSYNCI" . "Plicamycin"^^ . "41738"^^ . "MithramycinSYNCI" . "PlicamycinPTNCI" . . "mithramycinPTNCI-GLOSSCDR0000476348" . . . "NIJ123W41V"^^ . "Plicamycin"^^ . "FDA"^^ . "Antibiotic"^^ . "PA-144SYDTPNSC0024559" . "C658"^^ .