. "Fosinopril"^^ . "A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow.NCI" . . "98048-97-6"^^ . "R43D2573WO"^^ . "FosinoprilPTNCI" . "Fosinopril"^^ . "FOSINOPRILPTFDAR43D2573WO" . "C0118168"^^ . "C65761"^^ . . "C30H46NO7P"^^ . . "FDA"^^ . "Fosinopril"^^ . "CHEBI:5163"^^ . . . "Pharmacologic Substance"^^ .