"C64338"^^ . _:b698178 . "Nucleic Acid, Nucleoside, or Nucleotide"^^ . _:b698180 . _:b698178 . "Oral_Fludarabine_Phosphate"^^ . . _:b698179 . _:b698180 . "C1831839"^^ . _:b698179 . "Pharmacologic Substance"^^ . _:b698178 . _:b698179 . "An oral formulation of the phosphate salt of fludarabine, a synthetic purine nucleoside analogue antimetabolite with antineoplastic activity. Fudarabine is preferentially transported into malignant cells and metabolized by deoxycytidine kinase to its active form, 2-fluoro-ara-ATP; 2-fluoro-ara-ATP competes directly with deoxyadenosine triphosphate (dATP) and inhibits alpha DNA polymerase, RNA reductase, and DNA primase, which may result in inhibition of DNA synthesis and cell death.NCI" . _:b698180 . "Oral Fludarabine Phosphate"^^ . _:b698180 . "Oral Fludarabine Phosphate"^^ . _:b698178 . "486428"^^ . "Fludara OralBRNCI" . "Oral Fludarabine PhosphatePTNCI" . _:b698179 . . "486428"^^ . .