_:b698184 . _:b698185 . _:b698184 . _:b698181 . _:b698183 . "CL415081"^^ . "486610"^^ . _:b698182 . "Oral Ixabepilone"^^ . . "Pharmacologic Substance"^^ . "486610"^^ . "Oral Ixabepilone"^^ . _:b698181 . _:b698181 . _:b698182 . _:b698184 . _:b698185 . "Organic Chemical"^^ . _:b698185 . "Oral_Ixabepilone"^^ . "C63478"^^ . _:b698181 . _:b698182 . _:b698184 . _:b698183 . "Oral IxabepilonePTNCI" . . _:b698185 . "An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic activity. Ixabepilone binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in cell cycle arrest at the G2-M phase and leads to apoptosis within fast growing tumor cells. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Compared to intravenously administered ixabepilone, the oral formulation provides a more manageable way to administer this agent.NCI" . _:b698183 . . _:b698183 . _:b698182 .