_:b682259 . . _:b682260 . _:b682258 . "ImipraminePTDCP30354" . "FDA"^^ . _:b682259 . "OGG85SX4E4"^^ . "C0020934"^^ . . . _:b682258 . "50-49-7"^^ . . "Pharmacologic Substance"^^ . "A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. (NCI04)NCI" . "169866"^^ . . _:b682259 . "Imipramine"^^ . _:b682259 . . . "ImipraminePTNCI" . "Imipramine_Base"^^ . _:b682258 . _:b682260 . "Imipramine"^^ . _:b682258 . "CHEBI:47499"^^ . _:b682260 . "C19H24N2"^^ . "IMIPRAMINEPTFDAOGG85SX4E4" . _:b682260 . "C62039"^^ .