"J280872D1O"^^ . "DESONIDEPTFDAJ280872D1O" . "FDA"^^ . "C61702"^^ . "Dermatitis"^^ . . "638-94-8"^^ . "DesonateBRNCI" . . "CHEBI:204734"^^ . "A synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.NCI" . . "VerdesoBRNCI" . . . . "Desonide"^^ . "C0011705"^^ . "Desonide"^^ . "DesonidePTNCI" . "Desonide"^^ . "C24H32O6"^^ . "Pharmacologic Substance"^^ .