. "Ciclopirox"^^ . . . "Ciclopirox"^^ . "19W019ZDRJ"^^ . "Ciclopirox"^^ . . . "C12H17NO2"^^ . "C61677"^^ . "Pharmacologic Substance"^^ . "C0055711"^^ . "CiclopiroxPTNCI" . "29342-05-0"^^ . . . "CHEBI:453011"^^ . "A synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).NCI" . "FDA"^^ . "CICLOPIROXPTFDA19W019ZDRJ" .