"C0053799"^^ . . "FDA"^^ . . "Bisoprolol"^^ . "BisoprololPTNCI" . . "Pharmacologic Substance"^^ . "Bisoprolol"^^ . "A selective beta-1 adrenergic receptor antagonist with antihypertensive activity and devoid of intrinsic sympathomimetic activity. Bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, bisoprolol prevent the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels.NCI" . "C18H31NO4"^^ . "BISOPROLOLPTFDAY41JS2NL6U" . "66722-44-9"^^ . "CHEBI:3127"^^ . . . "Bisoprolol"^^ . "C61653"^^ . . "Y41JS2NL6U"^^ .