. . "Multitargeted AntifolateSYNCI" . "C0210657"^^ . . "698037"^^ . "137281-23-3"^^ . "PEMETREXEDPTFDA04Q9AIZ7NO" . "A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.NCI" . "C20H21N5O6"^^ . "Organic Chemical"^^ . "C61614"^^ . "Pemetrexed_Base"^^ . . "MTAABNCI" . "Pharmacologic Substance"^^ . "Pemetrexed"^^ . "FDA"^^ . "PemetrexedPTNCI" . . "Pemetrexed"^^ . "CHEBI:63616"^^ . "L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)SNNCI" . . "04Q9AIZ7NO"^^ . .